老年2型糖尿病患者脂代谢水平与认知功能的相关性

发布时间：2018-07-09 12:25

本文选题：型糖尿病 + 脂代谢　；参考：《中国老年学杂志》2016年15期

【摘要】：目的探讨老年2型糖尿病患者脂代谢水平与认知功能的相关性。方法随机抽取老年2型糖尿病入院患者150例,按总胆固醇(TC)值分为A组(TC5.2 mmol/L)、B组(TC 5.2 mmol/L~5.7 mmol/L)、C组(TC5.7 mmol/L)各50例,入院时均应用蒙特利尔认知评估量表(Mo CA)及简易精神状态量表(MMSE)测试其认知功能。结果 A组Mo CA因子分数及总分高于B、C组(P0.05,P0.01);B组的命名、抽象思维及记忆延迟因子的分数及总分明显高于C组(P0.01);B组的视空间、注意、语言、定向力因子分数高于C组(P0.05)。A组MMSE因子分数及总分与B组比较无统计学差异(P0.05),但明显高于C组(P0.01);B组的记忆力、回忆因子分数及总分明显高于C组(P0.01),而定向力、注意力及计算力、语言因子分数及总分分数高于C组(P0.05)。结论 TC、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白(Apo)A-I值越高,认知功能越好;甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、ApoB-100及脂蛋白a(Lpa)值越高,认知功能越差;极LDL-C(VLDL-C)值与认知功能无关。
[Abstract]:Objective to investigate the correlation between lipid metabolism and cognitive function in elderly type 2 diabetes mellitus. Methods 150 elderly patients with type 2 diabetes mellitus were randomly divided into two groups: group A (TC5.2 mmol / L), group B (TC 5.2 mmol / L) and group C (TC5.7 mmol / L). The cognitive function was measured by the Montreal Cognitive Assessment scale (MOCA) and the Mini-Mental State scale (MMSE) on admission. Results the scores and total scores of Mo CA factor in group A were higher than those in group B (P0.05 / P0.01). The scores and total scores of abstract thinking and memory retardation in group A were significantly higher than those in group C (P0.01). The score of directional force factor was higher than that of group C (P0.05). The score and total score of MMSE in group A were not significantly different from those in group B (P0.05), but significantly higher than those in group C (P0.01). The scores of recall factor and total score in group A were significantly higher than those in group C (P0.01), while the ability of orientation, attention and calculation were significantly higher than those in group C (P0.01). Language factor score and total score were higher than C group (P0.05). Conclusion High density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A-I and triglyceride (TG), low density lipoprotein cholesterol (LDL-C), ApoB-100 and lipoprotein a (LPA) are associated with lower cognitive function, while very low density lipoprotein cholesterol (VLDL-C) is not associated with cognitive function.
【作者单位】：武汉市中心医院心内科;
【分类号】：R587.1

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