炎性因子水平与糖尿病肾病分期的关系

发布时间：2018-07-11 15:53

本文选题：糖尿病肾病 + 白介素-　；参考：《中国全科医学》2017年S1期

【摘要】：目的探讨炎性因子水平与糖尿病肾病(DN)分期的关系。方法选取2014年5月—2016年5月江苏省宜兴市人民医院肾内科收治的2型糖尿病患者70例,根据尿微量清蛋白排泄率分为正常蛋白尿组(25例)、微量清蛋白尿组(22例)和大量蛋白尿组(23例),另选取同期在本院进行健康体检的自愿者25例作为对照组。采用酶联免疫吸附试验检测各组患者尿液白介素18(IL-18)和单核细胞趋化蛋白1(MCP-1)水平进行比较。结果 4组年龄、体质指数(BMI),舒张压比较,差异无统计学意义(P0.05);4组病程、收缩压、尿微量清蛋白比较,差异有统计学意义(P0.05);4组IL-18和MCP-1水平比较,差异有统计学意义(P0.05);4组空腹血糖(FPG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、超敏反应蛋白(hs-CRP)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)、尿素氮(BUN)及血肌酐(Scr)水平比较,差异有统计学意义(P0.05,)。结论炎性因子水平随着DN病情加重而升高,检测炎性因子水平可作为判断病情程度的辅助指标。
[Abstract]:Objective to investigate the relationship between the level of inflammatory factors and the stage of diabetic nephropathy (DN). Methods from May 2014 to May 2016, 70 patients with type 2 diabetes mellitus were selected from Department of Renal Medicine, Yixing City people's Hospital, Jiangsu Province. According to the urinary microalbumin excretion rate, the patients were divided into normal albuminuria group (n = 25), microalbuminuria group (n = 22) and large albuminuria group (n = 23). The levels of interleukin-18 (IL-18) and monocyte chemoattractant protein-1 (MCP-1) in urine were measured by enzyme-linked immunosorbent assay (Elisa). Results the age, body mass index (BMI), diastolic blood pressure (DBP) of the four groups were not significantly different (P0.05). There were significant differences in the levels of IL-18 and MCP-1 between the four groups (P0.05), including the course of disease, systolic blood pressure (SBP) and urine microalbumin (P 0.05). There were significant differences in fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), hypersensitive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor- 伪 (TNF- 伪), urea nitrogen (bun) and serum creatinine (SCR). The difference was statistically significant (P0.05,). Conclusion the level of inflammatory factors increases with the severity of DN, and the level of inflammatory factors can be used as an auxiliary index to judge the severity of DN.
【作者单位】：江苏省宜兴市人民医院;
【分类号】：R587.2;R692.9

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