甘精胰岛素注射液联合阿卡波糖片治疗继发性磺脲类药物失效的2型糖尿病的临床研究

发布时间：2018-07-13 12:17

【摘要】：目的观察甘精胰岛素注射液联合阿卡波糖片治疗磺脲类继发性失效的2型糖尿病患者的临床疗效。方法 80例磺脲类继发性失效的2型糖尿病患者均皮下注射甘精胰岛素注射液,每次10单位,每天1次;口服阿卡波糖片,每次50 mg,每天3次。治疗期间根据患者血糖变化对甘精胰岛素及阿卡波糖用量进行调整,疗程为3个月。观察治疗前后患者的临床疗效、血糖控制情况及药物不良反应发生情况。结果治疗后,临床总有效率为90.00%(72/80例)。治疗前,患者空腹血糖、餐后血糖、糖化血红蛋白(Hb A1c)含量分别为(9.34±2.04)mmol·L~(-1),(12.15±3.61)mmol·L~(-1),(8.82±2.53)%,治疗后,患者空腹血糖、餐后血糖、糖化血红蛋白含量分别为(6.23±1.26)mmol·L~(-1),(8.35±2.18)mmol·L~(-1),(6.64±1.23)%,差异有统计学意义(P0.05)。治疗过程中,头晕、心慌、出冷汗、视物模糊等药物不良反应发生率为8.75%(7/80例),对症治疗后消失。结论甘精胰岛素注射液联合阿卡波糖片治疗继发性失效的2型糖尿病患者,有效控制血糖水平,药物不良反应发生率低。
[Abstract]:Objective to observe the clinical effect of insulin glargine injection combined with acarbose tablets in the treatment of type 2 diabetes patients with secondary failure of sulfonylurea. Methods 80 patients with type 2 diabetes mellitus with secondary failure of sulfonylurea were treated by subcutaneous injection of insulin glargine (10 units per day) and oral acarbose tablets (50 mg / day, 3 times per day). During the treatment, the dosage of insulin and acarbose was adjusted according to the change of blood glucose. The course of treatment was 3 months. The clinical efficacy, blood glucose control and adverse drug reactions were observed before and after treatment. Results after treatment, the total effective rate was 90.00% (72 / 80 cases). Before treatment, the contents of fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin (HbA1c) were (9.34 卤2.04) mmol L-1), (12.15 卤3.61 mmol L-1), (8.82 卤2.53, respectively. After treatment, the fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin were (6.23 卤1.26) mmol L~ (-1), (8.35 卤2.18) mmol L~ (-1), (6.64 卤1.23), respectively (P0.05). In the course of treatment, the incidence of adverse drug reactions such as dizziness, panic, cold sweat and blurred vision was 8.75% (7 / 80 cases), and disappeared after symptomatic treatment. Conclusion Insulin glargine injection combined with acarbose tablet is effective in controlling blood glucose level and low incidence of adverse drug reactions in patients with type 2 diabetes mellitus with secondary failure.
【作者单位】：万宁市人民医院门诊部;万宁市人民医院内分泌科;
【基金】：海南省卫计委基层适宜技术推广基金资助项目[琼卫科教2015(74)号]
【分类号】：R587.1

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