血脂异常类型与摄食抑制因子-1、脂联素、瘦素的相关性研究

发布时间：2018-07-16 12:42

【摘要】：分析不同类型的高脂血症患者血清摄食抑制因子-1(NSF-1)、脂联素(ADP)、瘦素(LEP)水平的变化并探讨它们在脂代谢中的作用。纳入高胆固醇血症组87例,高甘油三酯血症组124例,混合型高脂血症组145例,低高密度脂蛋白血症组29例,健康对照组100例。比较五组临床参数的差异,分析血清NSF-1、ADP、LEP与甘油三酯(TG)、胆固醇(TC)等血脂组分的相关性。结果除低高密度脂蛋白血症组以外血脂异常类型各组的血清NSF-1、LEP水平均显著高于正常对照组;血脂异常各组的血清ADP水平均显著低于健康对照组;NSF-1与TC、TG、低密度脂蛋白胆固醇(LDL-C)呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关;ADP与TG、LDL-C呈负相关,与HDL-C呈正相关。LEP与TC、LDLC呈正相关;TG是NSF-1和ADP的独立影响因素,TC是LEP的独立影响因素。NSF-1、ADP、LEP共同参与脂代谢的调节,在高脂血症的发展进程中起着重要作用。
[Abstract]:The changes of serum intake inhibitor 1 (NSF-1), adiponectin (ADP) and leptin (LEP) levels in patients with different types of hyperlipidemia were analyzed and their roles in lipid metabolism were discussed. 87 cases of hypercholesterolemia group, 124 cases of hypertriglyceridemia group, 145 cases of mixed hyperlipidemia group, 29 cases of low density lipoproteinemia group and 100 cases of healthy control group were included. To compare the clinical parameters of the five groups, and to analyze the correlation between serum NSF-1ADP LEP and triglyceride (TG), cholesterol (TC) and other blood lipid components. Results the serum levels of NSF-1 and LEP in the dyslipidemia group except the low density lipoprotein group were significantly higher than those in the normal control group. The levels of serum ADP in dyslipidemia group were significantly lower than those in healthy control group (P < 0.01). The levels of low density lipoprotein cholesterol (LDL-C) and low density lipoprotein cholesterol (LDL-C) were positively correlated and negatively correlated with high density lipoprotein cholesterol (HDL-C). TG is an independent influencing factor of NSF-1 and ADP. TC is an independent factor of LEP. NSF-1ADPLEP is involved in the regulation of lipid metabolism and plays an important role in the development of hyperlipidemia.
【作者单位】：河北省人民医院;河北省计划生育科学技术研究院(国家卫计委计划生育与优生重点实验室);
【分类号】：R589.2

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