老年人血清瘦素水平与骨密度的相关性研究

发布时间：2018-07-16 09:57

【摘要】：目的：探讨新疆地区不同民族、不同性别老年人血清瘦素(Leptin,lep)水平与骨密度(BMD)的关系。方法：采用酶联免疫法(ELISA)测定74例老年人骨质疏松患者,111例骨量减少者和191例正常老年组患者,检测血清瘦素、骨密度等指标。通过对骨质疏松组、骨量减少组和骨量正常老年患者瘦素、骨密度(BMD)等指标的检测,比较各指标水平的差异,通过对维、汉两民族老年患者Lep水平、BMD等检测,分析两者的民族差异。通过对老年男女患者瘦素、骨密度等指标的检测,分析两者的性别差异。结果：血清Lep水平骨质疏松组低于正常组(P=0.000),骨量减少组低于正常组(P=0.036),骨量减少组低于骨质疏松组(P=0.019)。通过分析各组中民族和性别因素对瘦素水平的影响发现,民族和性别对于血清瘦素水平没有明显影响。老年人骨质疏松患者血清瘦素水平与患者BMD呈正相关(r=0.870,r=0.468均p0.01)；骨量减少患者血清瘦素水平与患者BMD呈正相关(r=0.477,r=0.467均p0.01)。结论：1.老年骨质疏松患者血清瘦素水平与BMD呈正相关,提示瘦素水平可能为老年骨质疏松的影响因素。2.维、汉两民族老年骨质疏松患者中的血清瘦素水平未发现明显差异。3.不同性别间老年骨质疏松患者的血清瘦素水平也未发现明显差异。
[Abstract]:Objective: To investigate the relationship between serum leptin (Leptin, LEP) level and bone mineral density (BMD) in different ethnic groups in Xinjiang. Methods: ELISA (ELISA) was used to measure 74 elderly patients with osteoporosis, 111 cases of osteopenia and 191 normal elderly patients, and the serum leptin and bone density were detected. In the loose group, the bone mass reduction group and the bone mass normal elderly patients, the indexes of leptin and bone mineral density (BMD) were measured, and the differences in the level of each index were compared. The ethnic differences were analyzed by testing the level of Lep and BMD in the elderly patients of the two ethnic groups of the Han Dynasty. The sex difference between the two elderly patients was analyzed by the detection of the indexes of leptin and bone density. Results: the serum Lep level in the osteoporosis group was lower than that of the normal group (P=0.000), the osteopenia group was lower than the normal group (P=0.036), and the osteopenia group was lower than the osteoporosis group (P=0.019). The results of the influence of ethnic and gender factors on leptin level in each group showed that the ethnic and gender had no significant influence on the serum leptin level. Serum leptin levels in patients with osteoporosis were positively correlated with patients' BMD (r=0.870, r=0.468 P0.01); serum leptin levels in patients with osteopenia were positively correlated with patients' BMD (r=0.477, r=0.467 P0.01). Conclusion: 1. the serum leptin levels in elderly patients with osteoporosis are positively correlated with BMD, suggesting that leptin levels may be the effect of osteoporosis in the elderly. Factor.2. dimension, there is no significant difference in serum leptin levels in the elderly patients with osteoporosis in the Han two ethnic groups. There is no significant difference in serum leptin levels between.3. and the elderly patients with osteoporosis.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R580

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