中药干预绝经后骨质疏松症的系统评价

发布时间：2018-07-15 21:26

【摘要】：一、绝经后骨质疏松症干预概况随着绝经后骨质疏松症发病率的逐年增加,绝经后骨质疏松症的防治越来越受到重视。大量临床试验对绝经后骨质疏松症干预的方案进行了研究,并探讨了各方案的有效性和安全性。生活方式、西药、中医药及相互联用的干预方式对绝经后骨质疏松症的防治均具有临床意义,然而目前临床面临的问题是,在众多的方案中如何针对不同患者进行个体化的干预措施的选择。通过查阅大量文献,笔者对已用于临床的干预方式、方法进行了文献研究,按照基础治疗、西药治疗、中医中药治疗的提纲对其干预研究及疗效进行了综述。通过综述进一步肯定了上述方案的有效性,并为下一步比较分析各方案有效性、安全性提供了初步的研究思路和文献证据。二、中药干预绝经后骨质疏松的系统评价目的：以对照组作为对照,评价中药干预绝经后骨质疏松症的疗效性和安全性。方法：按照Cochrane协作网的系统评价要求,电子检索Cochrane Library、 PubMed、中国生物医学文献数据库、清华同方CNKI数据库、维普中文科技期刊数据库、万方学位论文数据库、万方中华医学会期刊数据库,并手工检索相关期刊杂志。采用Revman5.2软件对筛选出的相关文献数据资料进行比较分析。结果：共纳入14篇文献,包括1119例糖尿病前期患者。综合分析显示：(1)中药与单纯西药比较,前者对中医临床证候的改善效果明显；(2)两者相比较,中药增加骨密度水平、血清雌二醇浓度,改善骨代谢指标、细胞因子水平的作用方面,表现出比使用单纯西药治疗更加确实的疗效,而且未发现明显或者严重不良反应；(3)两者安全性作用效果相当。结论：中药能够增加骨密度、血清雌二醇浓度,调节骨代谢,改善临床症状和中医证候,且其不良反应发生率较低,对临床绝经后骨质疏松症的预防具有重要意义。
[Abstract]:1. With the increasing incidence of postmenopausal osteoporosis, the prevention and treatment of postmenopausal osteoporosis are paid more and more attention. A large number of clinical trials were carried out to study the intervention scheme of postmenopausal osteoporosis, and the effectiveness and safety of each protocol were discussed. Lifestyle, western medicine, Chinese medicine and their combined intervention are all of clinical significance for the prevention and treatment of postmenopausal osteoporosis. However, the current clinical problems are: How to choose individual interventions for different patients in a wide range of programs. Through consulting a large number of literature, the author has carried on the literature research to the intervention method which has already used in the clinic, has carried on the literature research, according to the basic treatment, the western medicine treatment, the traditional Chinese medicine treatment outline has carried on the summary to its intervention research and the curative effect. The effectiveness of these schemes is further confirmed through a review, and preliminary research ideas and documentary evidence are provided for the further comparison and analysis of the effectiveness and safety of each scheme. Objective: to evaluate the efficacy and safety of traditional Chinese medicine in the treatment of postmenopausal osteoporosis. Methods: according to the systematic evaluation requirements of Cochrane Cooperative Network, we searched electronically the Cochrane Library, PubMed, Chinese Biomedical Literature Database, Tsinghua Tongfang CNKI Database, Weipu Chinese Science and Technology Journal Database and Wanfang dissertations Database. Wanfang Chinese Medical Association journal database, and manual retrieval of related journals. Using Revman 5.2 software, the selected literature data were compared and analyzed. Results: a total of 14 articles were included, including 1119 prediabetic patients. Comprehensive analysis shows that: (1) compared with western medicine, the former has obvious effect on the improvement of TCM clinical syndromes; (2) compared with traditional Chinese medicine, traditional Chinese medicine increases bone mineral density, serum estradiol concentration, and improves bone metabolism index. The effect of cytokine level was more effective than that of western medicine alone, and no obvious or serious adverse reactions were found. (3) the effect of safety was similar. Conclusion: traditional Chinese medicine can increase bone mineral density, serum estradiol concentration, regulate bone metabolism, improve clinical symptoms and TCM syndromes, and the incidence of adverse reactions is relatively low, which is of great significance for the prevention of postmenopausal osteoporosis.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R580

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