启宫丸汤联合化学药对多囊卵巢综合征合并不孕症患者血清激素水平的影响

发布时间：2018-07-17 18:05

【摘要】：目的:探讨启宫丸汤联合化学药对多囊卵巢综合征(PCOS)合并不孕症患者激素水平的影响。方法:选取2015年7月-2016年6月于我院妇科就诊的PCOS合并不孕症患者98例为研究对象,采用随机数字表法分为观察组和对照组,各49例。对照组患者于月经第5天起口服枸橼酸氯米芬片50 mg,qd,连续5 d;于月经第11天行B超监测卵泡发育情况,若无直径10 mm的优势卵泡则肌内注射注射用绒促性素2 000 U,隔日1次,至卵泡发育直径达18 mm。观察组患者在对照组基础上加用启宫丸汤,每日1剂,水煎取汁400 m L,早晚各服200 m L。治疗3个月后,比较两组患者血清卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2)、总睾酮(T)、硫酸脱氢表雄酮(DHEA-S)、性激素结合球蛋白(SHBG)水平,以及子宫内膜厚度、成熟卵泡数量和妊娠率。结果:治疗前,两组患者FSH、LH、PRL、E2、T、DHEA-S、SHBG水平比较,差异均无统计学意义(P0.05)。治疗3个月后,两组患者PRL、T、DHEA-S水平显著降低,E2、EHBG水平显著升高;且观察组患者FSH、PRL、T、DHEA-S水平显著低于对照组,E2、SHBG水平显著高于对照组,差异均有统计学意义(P0.05)。观察组患者子宫内膜厚度明显大于对照组,妊娠率(18.37%)明显高于对照组(4.08%),差异均有统计学意义(P0.05)。结论:启宫丸汤联合化学药治疗PCOS合并不孕症,有助于调节患者血清激素水平、提高妊娠率。
[Abstract]:Objective: to investigate the effect of Qigong Pill decoction combined with chemical drugs on hormone levels in patients with polycystic ovary syndrome (PCOS) complicated with infertility. Methods: 98 cases of PCOS complicated with infertility were selected from July 2015 to June 2016 in our hospital, and were divided into observation group (n = 49) and control group (n = 49). The control group took clomiphene citrate 50 mg / g QD for 5 days from the 5th day of menstruation and monitored follicle development with B-ultrasound on the 11th day of menstruation. If there was no dominant follicle of 10 mm in diameter, the control group received intramuscular injection of choriotropin 2 000 U once every other day. The diameter of follicle development was 18 mm. The patients in the observation group were treated with Qigong Pill decoction on the basis of the control group. The patients in the observation group were treated with 1 dose of Qigong Pill daily, 400 mL of water decoction, and 200 mL of each group in the morning and evening. After 3 months of treatment, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E2), total testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), sex hormone binding globulin (SHBG) and endometrial thickness were compared between the two groups. Number of mature follicles and pregnancy rate. Results: before treatment, there was no significant difference between the two groups in the level of DHEA-SnSHBG (P 0.05). After 3 months of treatment, the levels of PRL TnTHEA-S in the two groups were significantly lower than those in the control group (P0.05), and the level of E2HEA-S in the observation group was significantly lower than that in the control group (P 0.05), and the level of E2HEA-S in the observation group was significantly lower than that in the control group (P 0.05), and the level of DHEA-S in the observation group was significantly lower than that in the control group (P 0.05). The endometrial thickness in the observation group was significantly greater than that in the control group, and the pregnancy rate (18.37%) was significantly higher than that in the control group (4.08%), the difference being statistically significant (P0.05). Conclusion: Qigong Pill decoction combined with chemical drugs in the treatment of PCOS with infertility is helpful to regulate serum hormone level and improve pregnancy rate.
【作者单位】： 遵义市中医院妇科专家门诊;遵义市中医院妇产科;遵义市中医院内科;遵义市中医院门诊;
【分类号】：R711.6;R711.75
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本文编号：2130498