非糖尿病正常体质量人群的腰臀比与胰岛素抵抗的相关性

发布时间：2018-07-17 21:01

【摘要】：目的在非糖尿病正常体质量人群中探讨腰臀比与胰岛素抵抗的相关性,比较其在不同性别的差异。方法选择2012年6月~10月我国南方社区居民进行横断面筛查(n=2142)。将参与者分为男性组和女性组,并按腰臀比四分位数将男女各分为4组。HOMA-IR=[空腹血糖(FIG)_x空腹胰岛素(FINS)]/22.5,HOMA-IR做为胰岛素抵抗的评价指标。建立Logistic回归模型分析正常体质量人群中腰臀比与胰岛素抵抗的相关性,并比较其在不同性别中的差异。结果男性和女性正常体质量人群中胰岛素抵抗发生率分别为6.95%,11.47%。在女性非校正模型中,腰臀比与胰岛素抵抗显著相关(OR 6.60,95%CI 2.86 to 15.26,P0.001),校正潜在混杂因素如高血压史、冠心病史、吸烟史、锻炼情况、BMI后,二者仍具相关性(OR 3.28,95%CI 1.34 to 8.04,P=0.009)。结论在非糖尿病正常体质量人群中,女性腰臀比是胰岛素抵抗的独立危险因素。
[Abstract]:Objective to investigate the correlation between waist hip ratio (WHR) and insulin resistance (IR) in non-diabetic normal body mass population and to compare their gender differences. Methods from June to October, 2012, the residents of southern communities in China were selected for cross-sectional screening (nnm2142). Participants were divided into male group and female group. According to the WHR quartile, male and female were divided into 4 groups: HOMA-IR= [fasting blood glucose (FIG) x fasting insulin (fins)] / 22.5 HOMA-IR as the evaluation index of insulin resistance. Logistic regression model was established to analyze the correlation between waist-to-hip ratio and insulin resistance in normal body mass population, and to compare their differences in different genders. Results the incidence of insulin resistance in male and female normal body mass population was 6.95% and 11.47%, respectively. WHR was significantly correlated with insulin resistance (OR 6.6095 CI 2.86 to 15.26 P0.001) in a female uncorrected model. There was still a significant correlation between WHR and BMI after adjusting for potential confounding factors such as history of hypertension, coronary heart disease, smoking, and exercise (OR 3.2895 CI 1.34 to 8.04 P0.009). Conclusion female waist-hip ratio is an independent risk factor for insulin resistance in non-diabetic normal body mass population.
【作者单位】：南方医科大学第三附属医院肾内科;
【基金】：广州科技项目(201604020015) 2016临床研究启动计划(LC2016PY047)
【分类号】：R587.1

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