血清IFN-γ和IL-10及免疫球蛋白与艾滋病患者机会性感染的关系研究

发布时间：2018-07-20 08:53

【摘要】：目的研究分析血清γ-干扰素(IFN-γ)、白细胞介素-10(IL-10)及免疫球蛋白与人类免疫缺陷病毒(HIV)/艾滋病(AIDS)患者机会性感染的关系。方法选取2015年6月-2016年6月收治的AIDS患者50例,采用酶联免疫吸附法测定血清中IFN-γ、IL-10及免疫球蛋白水平。结果 50例HIV/AIDS患者中,机会性感染40例占80.00%,单一机会性感染11例占27.50%,2种及以上机会性感染29例占72.50%;机会性感染组患者IL-10、免疫球蛋白G(IgG)分别为(95.55±158.41)、(28.83±3.24)pg/ml,均显著高于未感染患者(10.22±19.10)、(11.24±2.22)pg/ml(P0.05),而IFN-γ(5.81±1.32)pg/ml则低于未感染患者(8.62±1.01)pg/ml,差异有统计学意义(P0.05),肺孢子菌感染患者IL-10为(19.71±27.82)pg/ml,均显著低于未感染患者(71.89±161.02)pg/ml(P0.05);肺孢子菌感染患者、结核分歧杆菌、马尔尼菲青霉菌、其他真菌感染患者IgG水平均高于未感染患者(P0.05);机会性感染组患者IgA与IgM水平与无感染患者,差异无统计学意义;50例患者中,好转39例,恶化或无变化7例,死亡4例。结论血清IL-10、IFN-γ与HIV/AIDS患者机会性感染的发生密切相关,低水平IL-10可降低机体对肺孢子菌的清除能力,IL-10与IFN-γ对疾病预后无明显关系。
[Abstract]:Objective to study the relationship between serum interferon 纬 (IFN- 纬), interleukin-10 (IL-10) and immunoglobulin and opportunistic infection in patients with human immunodeficiency virus (HIV) / AIDS. Methods the serum levels of IFN- 纬 IL-10 and immunoglobulin in 50 AIDS patients from June 2015 to June 2016 were measured by enzyme-linked immunosorbent assay (Elisa). Results in 50 HIV / AIDS patients, In the opportunistic infection group, IL-10 and immunoglobulin G were (95.55 卤158.41), (28.83 卤3.24) PG / ml, respectively, which were significantly higher than those in the uninfected group (10.22 卤19.10), (11.24 卤2.22 pg/ml, P0.05) and IFN- 纬 (5.81 卤1.32) pg/ml, respectively. The IL-10 level in Pneumocystis infection patients was (19.71 卤27.82) PG / ml, significantly lower than that in uninfected patients (71.89 卤161.02) pg/ml (P0.05). The IgG levels of mycobacterium tuberculosis, Penicillium marneffei and other fungal infections were higher than those of uninfected patients (P0.05), and the levels of IgA and IgM in opportunistic infection group were significantly higher than those in non-infected patients. There were 7 cases of deterioration or no change and 4 cases of death. Conclusion Serum IL-10 IFN- 纬 is closely related to the occurrence of opportunistic infection in HIV / AIDS patients. Low levels of IL-10 can reduce the ability of Pneumocystis clearance. IL-10 and IFN- 纬 have no significant relationship with disease prognosis.
【作者单位】：宁波市北仑区人民医院感染科;
【分类号】：R512.91

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