益气活血法对2型糖尿病亚临床血管病变患者颈动脉内膜中层厚度及血浆vWF、PAI-1的影响

发布时间：2018-07-24 14:22

【摘要】：目的:研究益气活血法对2型糖尿病(Type 2 diabetes mellitus,T2DM)亚临床血管病变患者颈动脉内膜中层厚度(intimal-medial thickness,IMT)、血浆血管性假血友病因子(von Willebrand factor,v WF)、纤溶酶原激活物抑制剂-1(plasminogen activator inhibitor 1,PAI-1)的影响。方法:采用随机、对照试验设计,将符合纳入标准的T2DM亚临床动脉粥样硬化(athero sclerosis,AS)患者180例,所有患者均采取常规口服降糖治疗,治疗用药及剂量根据患者病情选择,在此基础上,将180例患者随机分为观察组及对照组,观察组加用益气活血法干预治疗,共计90例患者,剩余90例作为对照组不加用益气活血法。疗程为6个月。治疗前后分别测量颈动脉IMT并检测血脂、血糖、v WF及PAI-1等指标。结果:治疗后,两组颈动脉IMT、斑块积分、TC、TG、LDL-C、FPG、Hb A1c均有降低,差异有统计学意义(P0.01,P0.05),观察组降低颈动脉IMT、斑块积分、TC、LDL-C的作用更明显(P0.01,P0.05)。同时,观察组的不稳定斑块检出率、v WF、PAI-1与本组治疗前及对照组治疗后比较明显降低,差异有统计学意义(P0.01,P0.05),对照组不稳定斑块检出率、v WF、PAI-1有下降趋势,但差异无统计学意义(P0.05)。结论:采用益气活血法治疗2型糖尿病亚临床血管病变患者,能够减轻颈动脉内膜中层厚度,缩小和稳定斑块,改善糖脂代谢,降低炎症因子表达,抑制炎症反应,保护血管内膜的作用。
[Abstract]:Objective: to study the effect of Yiqi Huoxue method on intimal-medial thicknessen IMT and plasminogen activator inhibitor 1 (PAI-1) in patients with type 2 diabetes mellitus (Type 2 diabetes mellitusus T2DM). Methods: one hundred and eighty patients with subclinical T2DM atherosclerosis (athero sclerosis as) were enrolled in a randomized, controlled trial. All patients were treated with routine oral hypoglycemic therapy, and the dosage and dosage were selected according to the patient's condition. On this basis, 180 patients were randomly divided into the observation group and the control group, the observation group was treated with the method of supplementing qi and activating blood circulation, the remaining 90 cases were treated with the method of supplementing qi and activating blood circulation. The remaining 90 cases as the control group were not treated with the method of supplementing qi and activating blood circulation. The course of treatment was 6 months. Carotid IMT was measured before and after treatment, blood lipids, blood glucose v WF and PAI-1 were measured. Results: after treatment, the carotid IMT, plaque score and plaque score in the two groups were significantly lower than those in the control group (P0.01P 0.05). In the observation group, the carotid IMT was decreased and the plaque score was more significant (P0.01P0.05). At the same time, the detection rate of unstable plaques in the observation group was significantly lower than that before treatment and after treatment in the control group (P0.01P 0.05), and the detection rate of the unstable plaque in the control group (v WFPPAI-1) showed a downward trend, but the difference was not statistically significant (P0.05). Conclusion: the treatment of subclinical vascular diseases of type 2 diabetes mellitus with Yiqi Huoxue method can reduce the intima-media thickness of carotid artery, reduce and stabilize plaque, improve glucose and lipid metabolism, reduce the expression of inflammatory factors and inhibit inflammatory reaction. Protective effect of vascular intima.
【作者单位】：绍兴市上虞中医医院;
【基金】：浙江省中医药科技计划项目(2014ZA117) 上虞区社会发展科技计划项目(虞科[2015]21号)
【分类号】：R587.2

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