维吾尔族2型糖尿病与锌转运蛋白-8基因单核苷酸多态性及其交互作用的相关性分析
发布时间：2018-07-26 17:52
【摘要】：目的探讨锌转运蛋白-8基因(SLC30A8)的4个单核苷酸多态性(SNP)位点与维吾尔族T2DM的关联,以及SNP位点间交互作用对T2DM易感性的影响。方法选取维吾尔族T2DM患者(病例组)和健康体检者(对照组),各932名。通过体格及生化检查获得临床资料,并进行SLC30A8基因多态性检测。结果 SLC30A8基因的4个SNP中,rs13266634基因型频率、等位基因频率分布在调整协变量前后,组间比较差异均有统计学意义(P0.05);rs13266634的风险等位基因为C[P0.05,OR(95%CI):1.186(1.031~1.364)];SLC30A8基因模型分析显示,调整协变量后,两组rs13666334的加性模型[OR(95%CI):0.841(0.722~0.980)]、rs3802177的显性基因模型[OR(95%CI):0.621(0.338~0.995)]、rs3802177-rs13266634单倍型(T-T)[OR(95%CI):0.846(0.734~0.976)]比较,差异有统计学意义(P0.05);广义多因子降维法(GMDR)分析显示,各SNP位点间协变量调整前后均无交互作用(P0.05)。结论SLC30A8基因rs13666334、rs3802177与维吾尔族T2DM的易感性有关,且rs13666334位点的突变呈保护作用,其风险等位基因C有累加性,rs3802177-rs13266634单倍型(T-T)可能是维吾尔族T2DM的保护因素之一。
[Abstract]:Objective to investigate the association of four single nucleotide polymorphisms (SNP) of zinc transporter gene (SLC30A8) with T2DM in Uygur nationality and the effect of interaction between SNP loci on susceptibility to T2DM. Methods 932 Uygur T2DM patients (case group) and healthy controls (control group) were selected. The clinical data were obtained by physical and biochemical examination, and the polymorphism of SLC30A8 gene was detected. Results the genotype frequency and allele frequency of rs13266634 in four SNP of SLC30A8 gene were significantly different before and after covariate adjustment (P0.05). The risk allele of rs13266634 was C [P0.05OR (95%CI): 1.186 (1.031 / 1.364)]. The additive model of rs13666334 [OR (95%CI): 0.841 (0.722 / 0.980)] OR (95%CI): 0.621 (0.3380.95)] rs3802177-rs13266634 haplotype (T-T) [OR (95%CI) 0.846 (0.7340.9976)] was significantly different (P0.05), and generalized multivariate reduction (GMDR) analysis showed that there was no interaction between SNP loci before and after adjustment (P0.05). Conclusion the SLC30A8 gene rs13666334rs3802177 is associated with the susceptibility of T2DM in Uygur nationality, and the mutation of rs13666334 site is protective. The risk allele C of rs3802177-rs13266634 haplotype (T-T) may be one of the protective factors of Uygur T2DM.
【作者单位】： 新疆医科大学第一附属医院 临床医学研究院新疆代谢性疾病重点实验室;乌鲁木齐市沙依巴克区疾病预防控制中心;新疆医科大学第一附属医院内分泌科;新疆医科大学公共卫生学院;新疆医科大学第一附属医院感染管理科;
【基金】：国家重点基础研究发展计划(973计划)(2012CB722403) 新疆重大疾病医学重点实验室开放课题(SKLIB-XJMDR-2014-Y4、SKLIB-XJMDR-2015Y7) 新疆研究生科研创新基金(XJGRI2013083) 新疆医科大学第一附属医院院内科研基金(2013ZRQN18)
【分类号】：R587.1
本文编号：2146827
[Abstract]:Objective to investigate the association of four single nucleotide polymorphisms (SNP) of zinc transporter gene (SLC30A8) with T2DM in Uygur nationality and the effect of interaction between SNP loci on susceptibility to T2DM. Methods 932 Uygur T2DM patients (case group) and healthy controls (control group) were selected. The clinical data were obtained by physical and biochemical examination, and the polymorphism of SLC30A8 gene was detected. Results the genotype frequency and allele frequency of rs13266634 in four SNP of SLC30A8 gene were significantly different before and after covariate adjustment (P0.05). The risk allele of rs13266634 was C [P0.05OR (95%CI): 1.186 (1.031 / 1.364)]. The additive model of rs13666334 [OR (95%CI): 0.841 (0.722 / 0.980)] OR (95%CI): 0.621 (0.3380.95)] rs3802177-rs13266634 haplotype (T-T) [OR (95%CI) 0.846 (0.7340.9976)] was significantly different (P0.05), and generalized multivariate reduction (GMDR) analysis showed that there was no interaction between SNP loci before and after adjustment (P0.05). Conclusion the SLC30A8 gene rs13666334rs3802177 is associated with the susceptibility of T2DM in Uygur nationality, and the mutation of rs13666334 site is protective. The risk allele C of rs3802177-rs13266634 haplotype (T-T) may be one of the protective factors of Uygur T2DM.
【作者单位】： 新疆医科大学第一附属医院 临床医学研究院新疆代谢性疾病重点实验室;乌鲁木齐市沙依巴克区疾病预防控制中心;新疆医科大学第一附属医院内分泌科;新疆医科大学公共卫生学院;新疆医科大学第一附属医院感染管理科;
【基金】：国家重点基础研究发展计划(973计划)(2012CB722403) 新疆重大疾病医学重点实验室开放课题(SKLIB-XJMDR-2014-Y4、SKLIB-XJMDR-2015Y7) 新疆研究生科研创新基金(XJGRI2013083) 新疆医科大学第一附属医院院内科研基金(2013ZRQN18)
【分类号】：R587.1
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