新诊断1型糖尿病患者胰岛功能及其影响因素的临床研究

发布时间：2018-07-26 18:22

【摘要】：目的:探讨新诊断1型糖尿病患者胰岛功能水平及其影响因素。方法 :选取2010年1月—2015年12月在南京医科大学第一附属医院内分泌科住院治疗的新诊断1型糖尿病患者105例,测糖化血红蛋白、胰岛自身抗体及HLA-A和-DR位点,控制血糖10 mmol/L后行混合餐试验,测血糖、胰岛素及C肽,计算峰值C肽≥0.2 nmol/L的比例,并采用Logistic回归分析影响新诊断1型糖尿病患者胰岛功能的因素。结果:89.5%的患者初诊时峰值C肽≥0.2 nmol/L。初诊年龄≤18岁(OR=0.08,95%CI:0.01~0.90),酮症或酮症酸中毒起病(OR=0.08,95%CI:0.01~0.83),携带高危HLA-A-DRB1基因单倍型(OR=0.07,95%CI:0.01~0.61),胰岛自身抗体阳性数2(OR=0.10,95%CI:0.01~0.87)者峰值C肽≥0.2 nmol/L率更低。结论 :1型糖尿病患者初诊时仍有部分胰岛功能。因此,胰岛功能不能作为鉴别诊断1型或2型糖尿病的唯一依据。新诊断1型糖尿病患者胰岛功能与初诊年龄、酮症或酮症酸中毒起病、HLA-A-DRB1基因单倍型及胰岛自身抗体有关。
[Abstract]:Objective: to investigate the islet function and its influencing factors in newly diagnosed type 1 diabetes mellitus. Methods: from January 2010 to December 2015, 105 newly diagnosed type 1 diabetic patients were enrolled in the Department of Endocrinology of the first affiliated Hospital of Nanjing Medical University. The glycosylated hemoglobin, islet autoantibodies and HLA-A and Dr sites were measured. After controlling blood glucose for 10 mmol/L, mixed meal test was performed to measure blood glucose, insulin and C-peptide, and the ratio of peak C-peptide 鈮，

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