牙周基础治疗对老年2型糖尿病牙周炎患者脂联素、炎症因子及糖代谢的影响

发布时间：2018-07-27 17:06

【摘要】：目的探讨牙周基础治疗对老年2型糖尿病(T2DM)牙周炎患者脂联素、炎症因子、糖代谢指标的影响。方法选择患有T2DM的老年牙周炎患者98例,采用随机数字表法分为对照组和观察组,每组49例。两组继续糖尿病的基础治疗,对照组给予口腔卫生指导,观察组在此基础行牙周基础治疗。观察比较两组治疗前后菌斑指数(PLI),探诊深度(PD),龈沟出血指数(SBI)、空腹血糖(FPG),餐后2 h血糖(2 h PG),糖化血红蛋白(Hb A1c),白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)-α、脂联素(APN)、载脂蛋白(Apo)A1水平。结果治疗后,两组PLI、PD、SBI均较治疗前显著降低(PLI对照组t=4.81,P=0.00,观察组t=9.32,P=0.00;PD对照组t=3.75,P=0.00:观察组t=7.54,P=0.00;SBI对照组t=4.74,P=0.00,观察组t=9.10,P=0.00),且观察组降低幅度明显优于对照组(均P0.05)。治疗后,对照组糖代谢指标较治疗前变化不显著(P0.05),观察组FPG、2 h PG及Hb A1c均较治疗前显著降低(t=2.45,P=0.008;t=5.61,P=0.00;t=2.40,P=0.008),较对照组治疗后显著降低(P0.05);两组IL-1β、IL-6、TNF-α水平均明显低于治疗前(IL-1β对照组t=5.13,P=0.00,观察组t=11.69,P=0.00,IL-6对照组t=14.59,P=0.00,观察组t=32.41,P=0.00;TNF-α对照组t=5.69,P=0.00观察组t=11.96,P=0.00),Apo A1、APN水平显著高于治疗前(APN对照组t=13.83,P=0.00,观察组t=16.75,P=0.00;Apo A1对照组t=2.43,P=0.01,观察组t=3.97,P=0.00)(P0.05),且观察组各指标均较对照组显著升高(均P0.05)。结论牙周基础治疗可以改善体内糖代谢,降低炎症因子水平,促进APN、Apo A1表达。
[Abstract]:Objective to investigate the effects of periodontal therapy on adiponectin, inflammatory factors and glucose metabolism in elderly patients with type 2 diabetes mellitus (T2DM). Methods 98 cases of senile periodontitis with T2DM were randomly divided into control group (n = 49) and observation group (n = 49). The two groups continued the basic treatment of diabetes, the control group was given oral hygiene guidance, the observation group was treated with periodontal basic therapy. The plaque index (PLI), probing depth (PD), gingival sulcus bleeding index (SBI), fasting blood glucose (FPG),) 2 h postprandial blood glucose (HbA1c), interleukin (IL) 1 尾 sil 6, tumor necrosis factor (TNF) 伪, adiponectin (APN), apolipoprotein (Apo) A1 were observed and compared between the two groups before and after treatment. Results after treatment, the levels of PLI in the control group were significantly lower than those in the control group (t = 4.81, P ~ (0.00), while in the control group, t ~ (3.75) P _ (P ~ (0.00); in the observation group, there was a significant difference between the control group and the control group (P < 0.05), and the decrease in the observation group was significantly higher than that in the control group (all P 0.05), and that in the observation group was significantly higher than that in the control group (all P 0.05), and that in the observation group was significantly higher than that in the control group (P < 0.05), while in the observation group, there was no significant difference between the two groups (P > 0.05). After treatment, There was no significant change in glucose metabolism in the control group (P0.05), but the levels of PG and HbA1c in the observation group were significantly lower than those before the treatment (t 2.45% P0. 008, P 0. 008), which were significantly lower than those in the control group (P0.05), and the levels of IL-1 尾-IL-6TNF- 伪 in the two groups were significantly lower than those before the treatment (IL-1 尾 control group, t5. 13P, P < 0. 008), while in the control group, the levels of IL-1 尾 -IL-6TNF- 伪 were significantly lower than those in the control group (P0.05), and the levels of TNF- 伪 in the two groups were significantly lower than those in the control group. The levels of APN in the control group were significantly higher than those before the treatment (APN control group, t13.83 P0. 00. the observation group was 16.75, the control group was t2.43 P0. 01, the observation group was t3.977P0.00) (P0.05), and each index in the observation group was significantly higher than that in the control group (P0.05), and the levels of APN in the observation group were significantly higher than those in the control group (all P 0.05). The levels of APN in the observation group were significantly higher than those in the control group (t 13.83 P0. 00. the observation group had a significant difference between the observation group and the control group (P 0.05). The results showed that the control group was significantly higher than that in the control group (P 0.05), and the control group was significantly higher than that in the control group (P 0.05), and the levels of APO A were significantly higher in the observation group than in the control group (P 0.05). Conclusion periodontal basic therapy can improve glucose metabolism, decrease the level of inflammatory factors and promote the expression of APN Apo A1 in vivo.
【作者单位】：浙江萧山医院口腔科;
【分类号】：R587.1;R781.42

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