糖尿病前期患者糖基化终产物与踝肱指数的相关研究
发布时间：2018-07-27 17:47
【摘要】：[目 的]：通过测定糖尿病前期患者糖基化终产物(AGEs)与踝肱指数(ABI),探讨二者之间的相关性,为糖尿病前期下肢动脉病变的早期干预提供依据。[方法]：收集糖尿病前期患者(PDM)50例、高血压患者(EH)28例,糖尿病前期合并高血压患者(PDMEH)25例以及对照组患者(NC)52例。所有入选研究对象均使用多普勒血流探测仪测定ABI以及酶联免疫吸附法测定AGEs浓度,并分析AGEs与ABI及其他指标的相关性。[结果]：1、经简单线性相关性分析：AGEs与ABI呈负相关,与LDL、FPG呈正相关；2、二分类Logistic回归分析：AGEs是ABI的危险因素。3、在糖尿病前期患者中,临界组(1.4≥ABI≥1.0)中AGEs含量明显高于正常组(0.9ABI1.0)(P0.05)；4、四组间年龄、WHR、TG、LDL、AGEs差异有统计学意义(P0.05)。[结论]：在糖尿病前期患者中,AGEs和ABI相关,ABI值越低的患者,AGEs含量越高。AGEs可能与下肢动脉病变的发病风险相关,但仍需进一步扩大样本证实。
[Abstract]:Objective: to investigate the correlation between (AGEs) and malleolus brachial index (ABI),) in patients with prediabetes by measuring the end product of glycosylation, and to provide evidence for early intervention of arterial lesions of lower extremities in prediabetic patients. [methods] 50 cases of (PDM), 28 cases of (EH), 25 cases of (PDMEH) and 52 cases of control group were collected. The concentration of ABI and AGEs were measured by Doppler flow detector and enzyme linked immunosorbent assay (Elisa), and the correlation between AGEs and ABI and other indexes were analyzed. [results] by simple linear correlation analysis, the ratio ages was negatively correlated with ABI and positively correlated with LDL-FPG. The two-classification Logistic regression analysis: ages was the risk factor of ABI. The level of AGEs in the critical group (1.4 鈮，
本文编号：2148665
[Abstract]:Objective: to investigate the correlation between (AGEs) and malleolus brachial index (ABI),) in patients with prediabetes by measuring the end product of glycosylation, and to provide evidence for early intervention of arterial lesions of lower extremities in prediabetic patients. [methods] 50 cases of (PDM), 28 cases of (EH), 25 cases of (PDMEH) and 52 cases of control group were collected. The concentration of ABI and AGEs were measured by Doppler flow detector and enzyme linked immunosorbent assay (Elisa), and the correlation between AGEs and ABI and other indexes were analyzed. [results] by simple linear correlation analysis, the ratio ages was negatively correlated with ABI and positively correlated with LDL-FPG. The two-classification Logistic regression analysis: ages was the risk factor of ABI. The level of AGEs in the critical group (1.4 鈮，
本文编号：2148665
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