邻苯二甲酸酯类暴露与人群肥胖关系的Meta分析

发布时间：2018-08-02 14:51

【摘要】：目的:采用Meta分析系统评价邻苯二甲酸酯类暴露与人群肥胖的关系,为预防和控制人群肥胖的发生提供新思路。方法:全面检索PubMed、Web of Science、The Cochrane Library、Elsevier Science Direct、OVID等外文数据库和中国生物医学文献数据库、中国知网数据库、维普数据库、万方数据库等中文数据库,查找国内外关于邻苯二甲酸酯类暴露与人群肥胖关系的中英文文献。根据纳入标准和排除标准筛选文献,提取纳入文献的相关数据,采用RevMan 5.3软件进行Meta分析。结果:最终纳入文献6篇,样本量共1 259例。Meta分析,肥胖人群尿液中邻苯二甲酸单丁酯(MBP)是正常人群的4.1倍(95%CI:1.43~6.76);而2组人群血清中邻苯二甲酸二丁酯(DBP)、邻苯二甲酸二乙基己酯(DEHP)和邻苯二甲酸二乙酯(DEP)水平的合并效应值分别为1.17(95%CI:0.64~1.69)、0.80(95%CI:0.13~1.48)和0.72(95%CI:-0.19~1.63),尿液中邻苯二甲酸单乙基己基酯(MEHP)和邻苯二甲酸单乙酯(MEP)水平的合并效应值分别为1.75(95%CI:-0.45~3.96)和2.75(95%CI:0.36~5.15),文献无异质性(P0.05)。结论:DBP代谢产物MBP水平升高与人群肥胖有关联,MBP可能会促进人群肥胖的发生。
[Abstract]:Objective: to evaluate the relationship between phthalate exposure and obesity by Meta analysis system, and to provide a new idea for prevention and control of obesity. Methods: the foreign language database such as Cochrane Library Elsevier Science DirectOVID, Chinese biomedical literature database, Chinese knowledge network database, Weip database, Wanfang database and so on were searched. To find the Chinese and English literature on the relationship between phthalate exposure and obesity at home and abroad. According to the inclusion criteria and exclusion criteria, the relevant data were extracted, and the Meta analysis was carried out with RevMan 5.3 software. Results: a total of 1 259 cases. Meta-analysis were included in 6 articles. The combined effects of dibutyl phthalate (DBP), diethyl hexyl phthalate (DEHP) and diethyl phthalate (DEP) in serum of obese people were 4.1 times as much as those of normal controls (95%CI:1.43~6.76). The combined effect values of monoethyl hexyl phthalate (MEHP) and monoethyl phthalate (MEP) in urine were 1.75 (95%CI:-0.45~3.96) and 2.75 (95%CI:0.36~5.15), respectively. There was no heterogeneity in literature (P0.05). Conclusion the increase of MBP level is associated with obesity.
【作者单位】：吉林大学公共卫生学院劳动卫生与环境卫生学教研室;
【基金】：国家自然科学基金资助课题(81573184)
【分类号】：R589.2

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