戒烟对烟草依赖支气管哮喘患者肺功能和生活质量的影响及伐尼克兰的辅助戒烟作用

发布时间：2018-08-02 18:40

【摘要】：目的探讨戒烟对烟草依赖支气管哮喘(简称哮喘)患者肺功能和生活质量的影响及伐尼克兰的辅助戒烟作用。方法收集2014年8月—2016年4月中山大学附属第三医院收治的符合纳入标准的44例吸烟的哮喘患者的临床资料。根据患者干预3个月后的戒烟状况,将其分为完全戒烟组(n=17)、部分戒烟组(n=14)和继续吸烟组(n=13)。比较3组患者哮喘控制情况[包括医生角度(干预后)和患者角度(干预前后),患者角度以哮喘控制测试表(ACT)评价],干预前后肺功能情况[第1秒用力呼气末容积占预计值百分比(FEV_1%pred)、用力肺活量占预计值百分比(FVC%pred)、第1秒用力呼气末容积占用力肺活量百分比(FEV_1/FVC)、晨间呼气峰流速(PEFam)、夜间呼气峰流速(PEFpm)]、生活质量[采用哮喘生活质量问卷简略版本(mini AQLQ)评价],伐尼克兰使用情况。结果 3组患者干预后哮喘控制情况(医生角度)比较,差异有统计学意义(P0.05)。3组患者干预前哮喘控制情况(患者角度)比较,差异无统计学意义(P0.05);完全戒烟组患者干预后哮喘控制情况(患者角度)优于继续吸烟组和部分戒烟组(P0.05)。3组患者干预前FEV_1%pred、FVC%pred、FEV_1/FVC、PEFam、PEFpm比较,差异无统计学意义(P0.05);3组患者干预后FEV_1/FVC比较,差异无统计学意义(P0.05);完全戒烟组患者干预后FEV_1%pred、PEFpm高于继续吸烟组(P0.05);继续吸烟组患者干预后FVC%pred、PEFam低于部分戒烟组、完全戒烟组(P0.05);干预后部分戒烟组、完全戒烟组患者FEV_1%pred、FVC%pred、PEFam、PEFpm高于干预前(P0.05)。3组患者干预前mini AQLQ评分比较,差异无统计学意义(P0.05);完全戒烟组患者干预后mini AQLQ评分高于继续吸烟组(P0.05)。3组患者伐尼克兰使用率比较,差异有统计学意义(P0.05)。结论伐尼克兰辅助戒烟可增加哮喘患者戒烟率,戒烟可改善吸烟哮喘患者病情、肺功能及生活质量。
[Abstract]:Objective to investigate the effects of smoking cessation on lung function and quality of life in patients with tobacco dependent bronchial asthma (Asthma). Methods the clinical data of 44 asthmatic patients who were admitted to the third affiliated Hospital of Sun Yat-sen University from August 2014 to April 2016 were collected. The patients were divided into complete smoking cessation group (n / 17), partial smoking cessation group (n / 14) and continuous smoking group (n / 13) according to their smoking cessation status after 3 months intervention. Three groups of patients with asthma control were compared [including doctor's angle (after intervention) and patient's angle (before and after intervention), the patient's angle was evaluated by asthma control test form (ACT), and the pulmonary function before and after intervention [forced expiratory end volume in 1 second]. Percentage of product to predicted value (FEV_1%pred), percentage of forced vital capacity to predicted value (FVC%pred), percentage of forced expiratory end-expiratory volume occupancy capacity (FEV_1/FVC), peak expiratory flow rate (PEFam),) in the morning, peak expiratory flow rate at night (PEFpm), quality of life [quality of life in asthma] Volume questionnaire brief version of (mini AQLQ) evaluation], Vannickland use. Results there were significant differences in asthma control (doctor's angle) between the three groups after intervention (P0.05). The asthma control status (patient angle) before intervention in group 3 was compared with that of the control group (P 0.05). There was no significant difference between the two groups (P0.05), the control of asthma after intervention in the complete smoking cessation group (P05) was better than that in the continued smoking group and partial smoking cessation group (P0.05). Before intervention, the FEV1predFVCpredFVCpredFVCpredFEV1 / FVC+ PEFamFamPEFFpm had no statistical significance (P0.05), and the difference was not statistically significant (P0.05). There was no significant difference between the two groups (P0.05); the FEVCpred1 PEFpm of the patients with complete smoking cessation was higher than that of the continuous smoking group (P0.05); the FVCpredPe Fam of the patients with continued smoking was lower than that of the partial smoking cessation group (P0.05); the partial smoking cessation group after intervention was lower than that of the complete smoking cessation group (P0.05), and that of the control group was lower than that of the control group (P0.05). There was no significant difference in the mini AQLQ score between the two groups before intervention (P0.05), the mini AQLQ score of the patients with complete smoking cessation after intervention was higher than that of the patients with continued smoking (P0.05), and the utilization rate of Vannickland was higher in the patients with complete smoking cessation (P0.05) than that in the patients before intervention (P0.05), the difference between the two groups was not significant (P0.05), but there was no significant difference between the two groups (P0.05). The difference was statistically significant (P0.05). Conclusion Vannickland can increase the rate of smoking cessation in asthmatic patients, and smoking cessation can improve the condition, pulmonary function and quality of life of asthmatic patients.
【作者单位】：中山大学附属第三医院呼吸内科;
【基金】：广东省科技计划项目(2016A020215220) 国家自然科学基金资助项目(81470220)
【分类号】：R562.25

【相似文献】