初诊2型糖尿病病人血清维生素D浓度与甲状腺功能及临床指标的关系

发布时间：2018-08-04 19:08

【摘要】：目的探讨初诊2型糖尿病(type 2 diabetes mellitus,T2DM)病人血清维生素D与甲状腺功能及临床指标的关系。方法选择北京市垂杨柳医院内分泌科2015年5月至2016年10月的初诊2型糖尿病病人239例,根据血清25-羟维生素D[25-hydroxy vitamin D,25(OH)D]值分为:≥30 ng/mL为正常组、20 ng/mL≤25(OH)D30 ng/mL为不足组、10 ng/mL≤25(OH)D20 ng/mL为缺乏组、10 ng/mL为严重缺乏组,比较血清25(OH)D与临床指标及甲状腺功能的关系。结果初诊2型糖尿病病人血清维生素D缺乏的患病率为56.9%,随着血清25(OH)D下降,年龄、糖化血红蛋白(glycosylate hemoglobin,HbA1c)、促甲状腺激素(thyroid stimulating hormone,TSH)逐渐增加,各组间比较差异有统计学意义(P0.05)。线性回归分析结果显示血钙(calcium,Ca)、甲状旁腺素(parathyroid hormone,PTH)与血清25(OH)D呈独立正相关(P0.05);性别、年龄、吸烟、HbA1c、TSH与血清25(OH)D呈独立负相关(P0.05)。结论女性、年龄、吸烟、HbA1c、TSH是初诊2型糖尿病病人血清25(OH)D缺乏的独立危险因素。
[Abstract]:Objective to investigate the relationship between serum vitamin D and thyroid function and clinical indexes in patients with newly diagnosed type 2 diabetes (type 2 diabetes mellitus, T2DM). Methods 239 patients with type 2 diabetes in the Department of endocrinology of Beijing Chui Yang Liu Hospital from May 2015 to October 2016 were selected, according to 25- hydroxyvitamin D[25-hydroxy vitamin D, 25 (OH) D] value. The results were as follows: 30 ng/mL as normal group, 20 ng/mL < 25 (OH) D30 ng/mL as inadequacy group, 10 ng/mL < 25 (OH) D20 ng/mL as a deficiency group, 10 ng/mL as a severe deficiency group, and comparison of serum 25 (OH) D and clinical indicators and thyroid function. Results the prevalence rate of vitamin deficiency in blood serum of first diagnosed type 2 diabetic patients was 56.9%, with 25 serum serum decreased, 25 Age, glycosylated hemoglobin (glycosylate hemoglobin, HbA1c), thyroid stimulating hormone (thyroid stimulating hormone, TSH) increased gradually, and there was a significant difference between each group (P0.05). The results of linear regression analysis showed that blood calcium (calcium, Ca), parathyroid adenine (parathyroid hormone) was independent positive correlation with serum 25. Sex, age, smoking, HbA1c, TSH and serum 25 (OH) D were independent negative correlation (P0.05). Conclusion women, age, smoking, HbA1c, TSH are independent risk factors of serum 25 (OH) D deficiency in patients with first diagnosed type 2 diabetes.
【作者单位】：北京市垂杨柳医院内分泌科;首都医科大学附属北京同仁医院内分泌科;糖尿病防治研究北京市重点实验室;
【基金】：国家自然科学基金(81370946,81400824,81300726) 北京市自然科学基金(7131005)~~
【分类号】：R587.1

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