异时联体共生模型在年龄相关疾病研究中的应用
发布时间：2018-08-08 13:29
【摘要】：组织、器官的衰老通常被认为是一个不可逆转的过程,但近期研究发现,通过联体共生模型或直接将年轻个体血液静脉注射到老年个体体内的方法,具有一定的对抗组织或器官衰老的作用。目前,相关研究已在干细胞衰老、心脑血管疾病、老年骨折愈合、骨骼肌细胞衰老等方面取得了诸多进展。联体共生(parabiosis)模型最初起源于19世纪,距今已有超过150年的历史,它是通过外科手术的方式,将两只动物连接在一起从而建立起共同的循环系统。作为沟通不同个体间循环系统的有效方式,联体共生模型具有广泛的应用前景。目前,联体共生模型所面临的主要挑战是联体后个体出现的"联体病"问题,"联体病"也被称为"联体中毒",它与手术过程无关,而是在联体手术两周后,伴随体外循环建立和血管再通而出现的一种状况,现有研究还不能解释这种现象出现的原因。虽然目前联体共生模型在世界上的应用还并不是十分广泛,但可以预测,联体共生模型必将为老年病的研究做出巨大的贡献。本文将从"联体共生模型"的历史、进展、挑战及前景几个方面进行综述。
[Abstract]:The aging of tissues and organs is often considered an irreversible process, but recent studies have found that, either through conjoined symbiotic models or by injecting blood directly into older individuals, It has the function of resisting the aging of tissues or organs. At present, many advances have been made in stem cell aging, cardiovascular and cerebrovascular diseases, fracture healing in the elderly and skeletal muscle cell senescence. The conjoined symbiotic (parabiosis) model originated in the 19th century and has a history of more than 150 years. It links the two animals together through surgery to establish a common circulatory system. As an effective way to communicate the circulatory system between different individuals, the conjoined symbiosis model has a wide application prospect. At present, the main challenge for conjoined symbiotic models is the "conjoined disease" that occurs in conjoined individuals, also known as "conjoined poisoning," which has nothing to do with the surgical process, but two weeks after conjoined surgery. With the establishment of cardiopulmonary bypass and the recanalization of blood vessels, existing studies have not yet explained the causes of this phenomenon. Although the conjoined symbiosis model is not widely used in the world, it can be predicted that the conjoined symbiosis model will make a great contribution to the study of geriatric diseases. This paper reviews the history, progress, challenges and prospects of the conjoined symbiotic model.
【作者单位】： 第二军医大学附属长海医院学员管理大队;第二军医大学海医系航空医学教研室;中韩生物医学工程中心;第二军医大学附属长海医院创伤骨科;
【基金】：国家自然科学基金国际合作项目(8141101156) 上海市科委生物医药专项(15411950600)
【分类号】：R592
，
本文编号：2171923
[Abstract]:The aging of tissues and organs is often considered an irreversible process, but recent studies have found that, either through conjoined symbiotic models or by injecting blood directly into older individuals, It has the function of resisting the aging of tissues or organs. At present, many advances have been made in stem cell aging, cardiovascular and cerebrovascular diseases, fracture healing in the elderly and skeletal muscle cell senescence. The conjoined symbiotic (parabiosis) model originated in the 19th century and has a history of more than 150 years. It links the two animals together through surgery to establish a common circulatory system. As an effective way to communicate the circulatory system between different individuals, the conjoined symbiosis model has a wide application prospect. At present, the main challenge for conjoined symbiotic models is the "conjoined disease" that occurs in conjoined individuals, also known as "conjoined poisoning," which has nothing to do with the surgical process, but two weeks after conjoined surgery. With the establishment of cardiopulmonary bypass and the recanalization of blood vessels, existing studies have not yet explained the causes of this phenomenon. Although the conjoined symbiosis model is not widely used in the world, it can be predicted that the conjoined symbiosis model will make a great contribution to the study of geriatric diseases. This paper reviews the history, progress, challenges and prospects of the conjoined symbiotic model.
【作者单位】： 第二军医大学附属长海医院学员管理大队;第二军医大学海医系航空医学教研室;中韩生物医学工程中心;第二军医大学附属长海医院创伤骨科;
【基金】：国家自然科学基金国际合作项目(8141101156) 上海市科委生物医药专项(15411950600)
【分类号】：R592
，
本文编号：2171923
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