泽泻对GK大鼠糖尿病治疗效果的评价

发布时间：2018-08-09 08:27

【摘要】：目的探讨单味中药泽泻与单味西药格列齐特对于糖尿病的治疗作用,评价中西药物对糖尿病治疗的差异。方法采用多变量重复测量设计,选择GK大鼠模型(Goto-Kakizaki wister rates,GK,原发性糖尿病大鼠模型)并将其分为泽泻组、格列齐特组、对照组,另选wistar大鼠为正常组,给药2周后观察GK大鼠和wistar大鼠体重、进食量、空腹血糖、糖耐量等指标,观测时间及不同处理间比较采用重复测量资料的方差分析,多重比较采用LSD法,综合评价中药、西药对于糖尿病治疗的效果差异性。结果和给药前相比,给药后泽泻组体重下降(P0.05),对照组、正常组、格列齐特组体重增加(P0.05),给药后泽泻组与其他三组比较体重下降(P0.05)；4组大鼠进食量在给药前后及组间均无统计学意义(P0.05)；和给药前相比,给药后泽泻组和格列齐特组空腹血糖下降,给药后泽泻组、格列齐特组与正常组比差异均有统计学意义(P0.05),但格列齐特组空腹血糖下降幅度较大,可以认为泽泻有改善糖尿病空腹血糖的作用且作用缓慢柔和；改善空腹血糖方面,格列齐特确实较泽泻组强且快(P0.05)；与给药前相比,给药后泽泻组糖耐量有明显的改善(P0.05),格列齐特组糖耐量变化无统计学意义(P0.05)。结论：1、单味中药泽泻、西药格列齐特有非常好的降低空腹血糖的作用。然而西药作为单一靶点研发的药物,在降低空腹血糖作用上较中药泽泻强。2、中药泽泻在控制空腹血糖时,又能控制体重、改善糖耐量异常,体现出中药泽泻作为一个混合物对于一个综合性疾病能起到多靶点干预的优势。
[Abstract]:Objective to explore the therapeutic effect of Alisma orientalis and gliclazide with single flavor and Western Medicine on diabetes, and to evaluate the difference between Chinese and Western Medicine on diabetes. Methods GK rat model (Goto-Kakizaki Wister rates, GK, primary diabetic rat model) was selected and divided into Alisma Alisma group and glitazide group. In the control group, the Wistar rats were selected as the normal group. After 2 weeks of administration, the weight, food intake, fasting blood glucose and glucose tolerance were observed in GK rats and Wistar rats. The observation time and the variance analysis of the repeated measurements were compared between the observation time and the different treatments. The multiple comparison of the LSD method was used to evaluate the difference of the effect of Western Medicine on the treatment of diabetes. The weight of Alisma orientalis group decreased (P0.05) after administration, and the weight of the control group, the normal group and the gliclazide group increased (P0.05). The weight loss of Alisma orientalis group was compared with the other three groups (P0.05). The 4 groups of rats had no statistical significance before and after the Administration (P0.05), and the Alisma orientalis group and Glee after administration. The fasting blood glucose decreased in the Zitt group, and there was a significant difference in the difference between the group of alisziziate and the normal group after administration (P0.05), but the fasting blood glucose decreased greatly in the glitazide group. It can be considered that Alisma orientalis has the effect of improving diabetic fasting blood glucose and the effect is slow and soft. Strong and fast (P0.05), compared with before administration, the sugar tolerance of Alisma orientalis group was obviously improved (P0.05), and the glucose tolerance of gliclazide group was not statistically significant (P0.05). Conclusion: 1, the single flavor Chinese Alisma orientalis, the western medicine gliclazide has a very good reduction in fasting blood glucose. However, western medicine as a single target research and development of drugs, in reducing fasting The effect of blood sugar is stronger than the Chinese medicine Alisma orientalis.2. The Chinese medicine Alisma orientalis can control the body weight and improve the abnormality of glucose tolerance when controlling the fasting blood glucose. It shows the superiority of the Chinese medicine Alisma orientalis as a mixture for a comprehensive disease.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1

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