绝经后骨质疏松症患者血清CEACAM1、β-catenin的变化及其与骨密度的关系

发布时间：2018-08-14 10:37

【摘要】：目的探讨癌胚抗原相关细胞黏附分子1(CEACAM1)、β-链蛋白(β-catenin)在绝经后骨质疏松症患者血清中的表达变化及与骨密度(BMD)的关系。方法 257例绝经后骨质疏松症患者为病例组,并于同期随机选取200例健康志愿者为对照组,采用ELISA法测定两组血清CEACAM1和β-catenin水平,采用双能X线吸收法测定两组L1~L4和双髋的BMD。对各指标间进行Pearson相关分析。结果病例组血清CEACAM1、β-catenin水平均低于对照组(P均0.05)。病例组腰椎、股骨颈BMD水平、T-score值、Z-score值均低于对照组(P均0.05)。病例组血清CEACAM1与β-catenin呈正相关(r=0.839,P0.05),血清CEACAM1与腰椎、股骨颈BMD均呈正相关(r分别为0.683、0.709,P均0.05),血清β-catenin与腰椎、股骨颈BMD呈正相关(r分别为0.725、0.671,P均0.05)。结论绝经后骨质疏松症患者血清CEACAM1和β-catenin水平降低,二者与BMD呈正相关关系。
[Abstract]:Objective to investigate the expression of carcinoembryonic antigen-associated cell adhesion molecule-1 (CEACAM1) and 尾 -catenin in postmenopausal patients with osteoporosis and the relationship between expression of 尾 -catenin and bone mineral density (BMD). Methods 257 postmenopausal osteoporosis patients were selected as the case group and 200 healthy volunteers as the control group. The serum CEACAM1 and 尾 -catenin levels were measured by ELISA method, and the L1~L4 and BMDs of the two groups were measured by dual energy X-ray absorptiometry. Pearson correlation analysis was carried out among the indexes. Results the serum levels of CEACAM1 and 尾-catenin in the case group were lower than those in the control group (P 0.05). The T-score and Z-score of BMD in lumbar vertebrae and femoral neck in the case group were lower than those in the control group (P < 0. 05). Serum CEACAM1 was positively correlated with 尾 -catenin (r 0.839 P 0.05), serum CEACAM1 was positively correlated with lumbar spine and femoral neck BMD (r = 0.683 卤0.709 P 0.05), serum 尾 -catenin was positively correlated with lumbar spine and femoral neck BMD (r = 0.725 0.671P 0.05, respectively). Conclusion the serum levels of CEACAM1 and 尾-catenin in postmenopausal osteoporosis patients were decreased, and there was a positive correlation between them and BMD.
【作者单位】：新疆生产建设兵团四师医院;
【基金】：新疆维吾尔自治区科技计划项目(201633132)
【分类号】：R580

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