骨髓间充质干细胞成骨分化相关信号通路及其与BMP-2关系的研究进展

发布时间：2018-08-14 12:23

【摘要】：骨髓间充质干细胞(BMSCs)的成骨分化涉及多条信号通路,包括NF-κB受体活化因子配体(RANKL)/NF-κB受体活化因子(RANK)/骨保护素(OPG)信号通路、Wnt/β-catenin信号通路、丝裂原活化蛋白激酶(MAPK)信号通路、Smad信号通路、Notch信号通路等。这些信号通路在调控BMSCs成骨分化方面具有重要作用,其中一条或数条信号通路调节受阻,均可引起BMSCs成骨分化异常,进而导致骨质疏松症等骨代谢疾病的发生。骨形态发生蛋白2(BMP-2)是骨生长的启动因子,可诱导BMSCs向成骨细胞分化并促进其发生钙化及矿化。在BMSCs成骨分化过程中,BMP-2与Wnt/β-catenin信号通路、ERK/MAPK信号通路、Notch三条信号通路均有一定联系。
[Abstract]:Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) involves several signal pathways, including NF- 魏 B receptor activator ligand (RANKL) / NF- 魏 B receptor activating factor (RANK) / osteoprotegerin (OPG) signaling pathway. Mitogen-activated protein kinase (MAPK) signaling pathway, Smad signaling pathway, Notch signaling pathway and so on. These signaling pathways play an important role in regulating the osteogenic differentiation of BMSCs. One or more of these signaling pathways are blocked, which can cause abnormal osteogenic differentiation of BMSCs and lead to the occurrence of bone metabolic diseases such as osteoporosis. Bone morphogenetic protein 2 (BMP-2) is the promoter of bone growth, which can induce the differentiation of BMSCs into osteoblasts and promote its calcification and mineralization. During the osteogenic differentiation of BMSCs, BMP-2 and Wnt/ 尾 -catenin signaling pathway ERK / MAPK signaling pathway and Notch signaling pathway are all related to each other.
【作者单位】：南京中医药大学医学与生命科学学院;江苏省中医院;
【基金】：江苏省自然科学基金面上项目(BK20131417)
【分类号】：R580

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