骨质疏松患者下颌骨随访的初步研究
发布时间：2018-08-17 12:07
【摘要】：目的初步研究下颌体、下颌支做为骨密度随访指标的临床意义。方法采用美国Norland XR-800双能X线骨密度仪,通过重复四次测定30例正常志愿者下颌骨骨密度,计算下颌体、下颌支重复性试验精确度变异系数百分比;通过测定30例正常志愿者及45例骨质疏松或骨量减少患者左股骨近端、正位腰椎、下颌骨骨密度,观察其骨密度的差异;通过测定20例用药患者6个月内左股骨近端、正位腰椎、下颌骨骨密度,随访观察股骨颈、Ward区、L2-4、下颌体、下颌支骨密度(BMD)随时间的变化规律及临床特点。结果 130例正常志愿者下颌体的重复性为2.08%,下颌支的重复性为2.75%,略高于Ward区的重复性变异系数2.27%。245例骨质疏松或骨量减少患者下颌体、下颌支BMD显著降低,与正常志愿者相比,差异有统计学意义(P0.05)。320例随访用药患者下颌骨BMD变化先于其它部位出现,下颌支BMD四周即可发生变化,早于下颌体。结论下颌骨骨密度变化敏感性高,非常适合做为骨质疏松患者的临床随访指标,优于其他部位的骨密度测量。
[Abstract]:Objective to study the clinical significance of mandibular body and mandibular branch as bone mineral density (BMD) follow-up index. Methods the mandibular bone mineral density (BMD) of 30 normal volunteers was measured four times by Norland XR-800 dual energy X-ray absorptiometry, and the accuracy coefficient of variation percentage of mandibular body and mandibular branch reproducibility test was calculated. The bone mineral density (BMD) of the proximal end of the left femur, lumbar vertebrae and mandible in 30 normal volunteers and 45 patients with osteoporosis or osteopenia were measured, and the proximal end of the left femur was measured in 20 patients within 6 months. Bone mineral density (BMD) of anterior lumbar vertebrae and mandible were observed. The changes of bone mineral density (BMD) and clinical characteristics of L2-4, mandibular body and mandibular branch in the Ward area of femoral neck were observed. Results the reproducibility of mandibular body and mandibular branch was 2.08 and 2.75 in 130 normal volunteers, slightly higher than that in Ward area, the coefficient of variation of repeatability was 2.27.245 cases of osteoporosis or osteopenia. The BMD of mandibular Rami was significantly lower than that of normal volunteers. The difference was statistically significant (P0.05) .320 patients were followed up the changes of mandibular BMD appeared earlier than other parts of the mandible, the mandibular Rami BMD could change around four weeks, earlier than the mandibular body. Conclusion mandibular bone mineral density has high sensitivity and is suitable for clinical follow-up in patients with osteoporosis and is superior to other bone mineral density measurements.
【作者单位】： 清华大学医院放射科;清华大学医院骨科;
【基金】：清华大学医院科学研究基金(110200004)
【分类号】：R580
[Abstract]:Objective to study the clinical significance of mandibular body and mandibular branch as bone mineral density (BMD) follow-up index. Methods the mandibular bone mineral density (BMD) of 30 normal volunteers was measured four times by Norland XR-800 dual energy X-ray absorptiometry, and the accuracy coefficient of variation percentage of mandibular body and mandibular branch reproducibility test was calculated. The bone mineral density (BMD) of the proximal end of the left femur, lumbar vertebrae and mandible in 30 normal volunteers and 45 patients with osteoporosis or osteopenia were measured, and the proximal end of the left femur was measured in 20 patients within 6 months. Bone mineral density (BMD) of anterior lumbar vertebrae and mandible were observed. The changes of bone mineral density (BMD) and clinical characteristics of L2-4, mandibular body and mandibular branch in the Ward area of femoral neck were observed. Results the reproducibility of mandibular body and mandibular branch was 2.08 and 2.75 in 130 normal volunteers, slightly higher than that in Ward area, the coefficient of variation of repeatability was 2.27.245 cases of osteoporosis or osteopenia. The BMD of mandibular Rami was significantly lower than that of normal volunteers. The difference was statistically significant (P0.05) .320 patients were followed up the changes of mandibular BMD appeared earlier than other parts of the mandible, the mandibular Rami BMD could change around four weeks, earlier than the mandibular body. Conclusion mandibular bone mineral density has high sensitivity and is suitable for clinical follow-up in patients with osteoporosis and is superior to other bone mineral density measurements.
【作者单位】： 清华大学医院放射科;清华大学医院骨科;
【基金】：清华大学医院科学研究基金(110200004)
【分类号】：R580
【参考文献】
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1 孙蕴;贺丽英;马兆坤;潘克h，
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