青海地区藏汉族2型糖尿病临床特点比较分析
发布时间：2018-08-27 14:36
【摘要】：目的通过对青海地区藏汉族2型糖尿病(T2DM)患者临床特点进行比较,探讨藏族T2DM临床特点、发生发展的病理特点及其可能影响因素。方法收集2014年1月-2015年12月青海大学附属医院内分泌科诊断为T2DM(均符合1999年WHO的DM诊断标准)的藏汉族同期住院患者的临床资料。进行比较分析。结果藏汉族非体力劳动患者构成比均较高。藏族患者在腰围、BMI、HbAlc、FPG、血糖曲线下总面积、LDL-C、ALT、WBC、MCHC、PLT、PCT、HOMA-IR临床指标方面显著高于汉族,具有统计学意义(分别P0.05),但口服100g馒头OGTT试验中的C肽曲线下反应面积、HDL-C、ALB、MPV、PDW方面又显著低于汉族,具有统计学意义(分别P0.05)。上述特点藏族男性表现较为突出。但慢性并发症及代谢综合征患病率方面藏汉族并无明显区别。结论结果提示较高的肥胖体质是藏族T2DM患者的重要临床表现,其胰岛素抵抗程度高于汉族患者,这可能与肥胖合并肝脏损害有关。与汉族相比,藏族患者所具有较高的LDL-C可能与其生活方式不无关系。其血糖水平的增高除上述因素外,胰岛细胞功能的下降亦是其重要原因之一。尽管藏族民族特点、居住海拔和汉族存在一些差异,但藏汉族T2DM慢性并发症及代谢综合征患病率方面并无显著统计学意义,提示它们发生的病理机制可能是一致的。因此改善体力活动和饮食结构有可能是预防高原DM的必要措施。
[Abstract]:Objective to compare the clinical characteristics of type 2 diabetes mellitus (T2DM) in Tibetan and Han nationality in Qinghai, and to explore the clinical characteristics, pathological characteristics and possible influencing factors of Tibetan T2DM. Methods from January 2014 to December 2015, the clinical data of patients with T2DM diagnosed by Endocrinology Department of affiliated Hospital of Qinghai University (all in accordance with the DM diagnostic criteria of 1999 WHO) were collected. A comparative analysis was carried out. Results the composition ratio of non-manual labor patients in Tibetan and Han nationality was higher than that in Han nationality. In Tibetan patients, the total area under the blood glucose curve was significantly higher than that in the Han nationality (P 0.05), but the response area under the C-peptide curve of 100g steamed bread OGTT test was significantly lower than that of the Han nationality (P < 0.05), and the total area under the blood glucose curve was significantly lower than that of the Han nationality (P < 0.05), and the total area under the blood glucose curve was significantly lower in the Tibetan patients than that in the Han nationality (P < 0.05), but the response area under the C-peptide curve in the 100g OGTT test was significantly lower than that in the Han nationality (P < 0.05). There was statistical significance (P0.05). The above characteristics of Tibetan male performance is more prominent. However, there was no significant difference in the prevalence of chronic complications and metabolic syndrome between Tibetan and Han nationality. Conclusion the results suggest that higher obesity constitution is an important clinical manifestation of Tibetan patients with T2DM, and the degree of insulin resistance is higher than that of Han nationality patients, which may be related to obesity with liver damage. Compared with the Han nationality, the higher LDL-C of Tibetan patients may be related to their lifestyle. In addition to the above factors, the decrease of islet cell function is one of the important reasons. Although there were some differences between Tibetan nationality and Han nationality, there was no significant difference in the prevalence of chronic complications and metabolic syndrome of T2DM in Tibetan and Han nationality, suggesting that the pathogenetic mechanism of them might be the same. Therefore, improving physical activity and dietary structure may be the necessary measures to prevent DM at high altitude.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R587.1
本文编号：2207578
[Abstract]:Objective to compare the clinical characteristics of type 2 diabetes mellitus (T2DM) in Tibetan and Han nationality in Qinghai, and to explore the clinical characteristics, pathological characteristics and possible influencing factors of Tibetan T2DM. Methods from January 2014 to December 2015, the clinical data of patients with T2DM diagnosed by Endocrinology Department of affiliated Hospital of Qinghai University (all in accordance with the DM diagnostic criteria of 1999 WHO) were collected. A comparative analysis was carried out. Results the composition ratio of non-manual labor patients in Tibetan and Han nationality was higher than that in Han nationality. In Tibetan patients, the total area under the blood glucose curve was significantly higher than that in the Han nationality (P 0.05), but the response area under the C-peptide curve of 100g steamed bread OGTT test was significantly lower than that of the Han nationality (P < 0.05), and the total area under the blood glucose curve was significantly lower than that of the Han nationality (P < 0.05), and the total area under the blood glucose curve was significantly lower in the Tibetan patients than that in the Han nationality (P < 0.05), but the response area under the C-peptide curve in the 100g OGTT test was significantly lower than that in the Han nationality (P < 0.05). There was statistical significance (P0.05). The above characteristics of Tibetan male performance is more prominent. However, there was no significant difference in the prevalence of chronic complications and metabolic syndrome between Tibetan and Han nationality. Conclusion the results suggest that higher obesity constitution is an important clinical manifestation of Tibetan patients with T2DM, and the degree of insulin resistance is higher than that of Han nationality patients, which may be related to obesity with liver damage. Compared with the Han nationality, the higher LDL-C of Tibetan patients may be related to their lifestyle. In addition to the above factors, the decrease of islet cell function is one of the important reasons. Although there were some differences between Tibetan nationality and Han nationality, there was no significant difference in the prevalence of chronic complications and metabolic syndrome of T2DM in Tibetan and Han nationality, suggesting that the pathogenetic mechanism of them might be the same. Therefore, improving physical activity and dietary structure may be the necessary measures to prevent DM at high altitude.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R587.1
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1 徐斐斐;青海地区藏汉族2型糖尿病临床特点比较分析[D];青海大学;2016年
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