贵州省接受抗病毒治疗艾滋病患者的生存因素分析

发布时间：2018-08-28 13:15

【摘要】：目的了解贵州省人类免疫缺陷病毒(HIV)感染者和艾滋病(AIDS)患者接受抗逆转录病毒治疗后的生存时间及其影响因素。方法采用回顾性队列研究方法,分析贵州省2005—2016年接受抗病毒治疗的AIDS患者的生存时间,应用寿命表法计算生存概率,运用Cox比例风险回归模型分析其影响因素。结果共纳入分析15921例AIDS患者,开始治疗时的平均年龄为(42.13±14.40)岁,已婚/同居者占58.61%。治疗后患者的随访时间[中位数(P25~P75):15.96(6.00~33.00)]月。9.77%随访病例发生死亡,其中59.29%的死亡发生在开始治疗的12个月内;第1、5、10年的生存率分别为93.00%,82.00%和74.00%。Cox比例风险回归模型分析结果显示:女性患者死亡风险是男性的0.58倍(95%CI:0.49~0.68);随着年龄增高,患者死亡风险亦增高;基线CD4+T淋巴细胞计数越高,患者死亡风险越低;治疗前无疾病症状体征的患者死亡风险是有症状体征的0.70倍(95%CI:0.60~0.81)。结论贵州省AIDS患者抗病毒治疗情况整体较好,应高度关注死亡危险因素较高的患者,建议在扩增治疗患者的同时注重提高医疗水平和服务质量。
[Abstract]:Objective to investigate the survival time and its influencing factors of (HIV) infected with HIV and (AIDS) patients with HIV / AIDS in Guizhou province. Methods A retrospective cohort study was used to analyze the survival time of AIDS patients receiving antiviral therapy from 2005 to 2016 in Guizhou Province. The survival probability was calculated by life table method and the influencing factors were analyzed by Cox proportional risk regression model. Results A total of 15921 patients with AIDS were analyzed. The mean age at the beginning of treatment was (42.13 卤14.40) years, and the married / cohabitant was 58.61 years old. The follow-up time after treatment [median (P25~P75): 15.96 (6.00 卤33.00) months] was 9.77%, of which 59.29% occurred within 12 months of initial treatment. The survival rate was 93.00% and 82.00%, respectively. The results of 74.00%.Cox proportional risk regression model showed that the risk of death in female patients was 0.58 times higher than that in men (95%CI:0.49~0.68), and the risk of death also increased with age. The higher the T lymphocyte count of baseline CD4 was, the higher the risk of death was. The lower the risk of death, the higher the risk of death in patients without symptoms and signs prior to treatment (95%CI:0.60~0.81). Conclusion the antiviral therapy of AIDS patients in Guizhou province is good, so we should pay close attention to the patients with high risk factors of death. We suggest that we should pay attention to the improvement of medical treatment level and service quality while expanding the patients.
【作者单位】：贵州省疾病预防控制中心;贵州省人民医院;
【基金】：贵州省科技计划项目(黔科合SY[2013]3052号)
【分类号】：R512.91

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