健脾化浊散联合二甲双胍治疗肥胖2型糖尿病的临床研究

发布时间：2018-08-30 09:44

【摘要】：目的:观察健脾化浊散联合二甲双胍治疗肥胖2型糖尿病的临床疗效。方法:将120例患者随机分为2组,治疗组与对照组各60例。在基础治疗相同的情况下,对照组给予口服盐酸二甲双胍片,治疗组在对照组基础上加用健脾化浊散。观察患者临床疗效及治疗前后空腹血糖(fasting blood glucose,FBG)、餐后2h血糖(postprandial 2h blood glucose,P2h BG)、糖化血红蛋白(haemoglobin A1C,HbA1c)、空腹胰岛素(fasting insulin,FINS)、体质量指数(body mass index,BMI)、胰岛素抵抗指数(insulin resistance index,HOMA-IR)等变化情况。结果:治疗3个月后,2组均能有效降糖和减肥,治疗组降糖和减肥有效率[89.286%(50/56)、92.857%(52/56)]明显高于对照组[74.545%(41/55)、76.364%(42/55)],差异有统计学意义(P=0.026、P=0.047)。经治疗后2组的FBG、P2h BG、HbA1c、FINS、HOMA-IR及BMI较治疗前均降低(P=0.000)。治疗组FBG、P2h BG、HbA1c、FINS、HOMA-IR及BMI均较对照组降低(P=0.000)。结论:健脾化浊散联合二甲双胍可有效治疗肥胖2型糖尿病。
[Abstract]:Objective: to observe the clinical effect of Jianpi Huazhuo Powder (Jianpi Huazhuo Powder) combined with metformin in the treatment of obese type 2 diabetes mellitus. Methods: 120 patients were randomly divided into two groups, 60 cases in treatment group and 60 cases in control group. In the same condition of basic treatment, the control group was given metformin hydrochloride tablets orally, and the treatment group was treated with Jianpi Huazhuo Powder on the basis of the control group. The changes of fasting blood glucose (fasting blood glucose,FBG), postprandial blood glucose (postprandial 2h blood glucose,P2h BG), HbA1c), fasting insulin (fasting insulin,FINS), body mass index (body mass index,BMI) and insulin resistance index (insulin resistance index,HOMA-IR) were observed before and after treatment. Results: after 3 months of treatment, the effective rate of reducing glucose and reducing weight in the treatment group [89.286% (50 / 56), 92.857% (52 / 56)] was significantly higher than that in the control group [74.545% (41 / 55), 76.364% (42 / 55)]. The difference was statistically significant (P 0.026 P 0.047). After treatment, FBG,P2h BG,HbA1c,FINS,HOMA-IR and BMI in both groups were lower than those before treatment (P < 0. 000). FBG,P2h BG,HbA1c,FINS,HOMA-IR and BMI in the treatment group were lower than those in the control group (P0. 000). Conclusion: Jianpi Huazhuo Powder combined with metformin can effectively treat obese type 2 diabetes.
【作者单位】： 川北医学院附属医院中医科;
【基金】：四川省教育厅重点资助项目(编号:16ZA0225)
【分类号】：R587.1
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本文编号：2212704