椎体成形结合抗骨质疏松治疗减少再骨折发生率

发布时间：2018-09-02 05:39

【摘要】：背景:目前骨质疏松性椎体压缩性骨折患者常见,但缺乏规范抗骨质疏松治疗,使得治疗后再骨折问题逐渐显现。目的:探讨椎体成形技术配合抗骨质疏松治疗骨质疏松性椎体压缩性骨折后减少再骨折发生率方面的疗效,分析抗骨质疏松治疗的重要性。方法:纳入89例骨质疏松性椎体压缩性骨折患者,所有患者均行椎体成形/椎体后凸成形治疗,根据患者是否接受规范的抗骨质疏松治疗分为治疗组38例、对照组51例,通过门诊或住院随访复查胸/腰椎X射线片及骨密度值,对比两组在随访不同时间的脊柱稳定性、骨密度值及椎体再骨折发生率。结果与结论:(1)78例获得完整随访,随访6-39个月,平均26.73个月,治疗组、对照组在脊柱稳定性方面差异无显著性意义(P0.05),但对照组椎体骨小梁稀少;(2)骨密度值:两组治疗后12,24,36个月T值差异有显著性意义(P0.05);(3)再骨折发生率:治疗组明显低于对照组,差异有显著性意义(P0.05);(4)结果表明,骨质疏松性椎体压缩性骨折椎体成形治疗后规范的抗骨质疏松治疗可有效减少再骨折发生率,近、中期疗效满意。
[Abstract]:Background: at present, osteoporosis vertebral compression fracture patients are common, but lack of standardized anti-osteoporosis treatment, make the problem of re-fracture gradually appear after treatment. Objective: to investigate the effect of vertebroplasty combined with anti-osteoporosis in reducing the incidence of refracture after osteoporotic vertebral compression fracture, and to analyze the importance of anti-osteoporosis treatment. Methods: 89 patients with osteoporotic vertebral compression fracture were treated with vertebroplasty / kyphoplasty. According to whether the patients received regular anti-osteoporosis treatment, they were divided into treatment group (n = 38) and control group (n = 51). The spine stability, bone mineral density and the incidence of vertebral refracture were compared between the two groups after out-patient or in-patient follow-up. Results and conclusion: (1) 78 cases were followed up for 6-39 months (mean 26.73 months). There was no significant difference in spinal stability in the control group (P0.05), but the bone trabeculae in the control group were scarce; (2) bone mineral density: after treatment, there was significant difference in T value between the two groups (P0.05); (3): the incidence of refracture in the treatment group was significantly lower than that in the control group. The difference was significant (P0.05); (4). The results showed that the standard anti-osteoporosis treatment after vertebroplasty treatment for osteoporotic vertebral compression fracture could effectively reduce the incidence of refracture and the curative effect was satisfactory in the near and medium term.
【作者单位】：广州医科大学附属第三医院骨科;
【基金】：广东省科技计划项目(2014A020212355) 广东省研究生教育创新计划项目-创新强校(B158035)~~
【分类号】：R687.3;R580

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