甘油三酯与高密度脂蛋白胆固醇比值与老年人代谢综合征的相关性

发布时间：2018-09-05 11:12

【摘要】：目的探讨甘油三酯(TG)与高密度脂蛋白胆固醇(HDL-C)比值与老年人代谢综合征(MS)的相关性。方法采用整群随机抽样的方法,抽取任丘市100个村和20个社区,年龄60~70岁任丘市常住居民5 010例。将研究对象分为MS组和非MS组。检测两组血脂、血糖、血压、体重指数(BMI)、腰围(WC)等水平,计算TG/HDL-C。采用受试工作曲线(ROC)得出TG/HDL-C对MS预测的最佳切点。结果 MS组与非MS组TG/HDL-C[1.68(1.22,2.48)vs 0.73(0.52,1.03)]比较差异显著(P0.05)。根据TG/HDL-C水平的四分位数分组,随着TG/HDL-C水平的增高,男女性别各组间BMI、WC、腰身指数(WHtR)、TG、尿酸(UA)、胰岛素水平(INS)、胰岛素抵抗(HOMA-IR)均逐渐升高,女性空腹血糖(FPG)逐渐升高,男女组HDL-C逐渐降低(P0.05)。ROC分析,在老年男性人群中,当TG/HDL-C切值取1.11时,对MS的诊断效率最高,曲线下面积为0.873[P=0.000,95%CI(0.854,0.892)],灵敏度为79.3%、特异度为83.8%;在老年女性人群中,当TG/HDL-C切值取1.19时,对MS的诊断效率最高,曲线下面积为0.846[P=0.000,95%CI(0.831,0.861)],灵敏度为77.7%、特异度为81.1%。结论 TG/HDL-C与MS密切相关,对老年人群MS的早期预测和预防有重要意义。
[Abstract]:Objective to investigate the relationship between the ratio of triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) and (MS) in elderly patients with metabolic syndrome. Methods A total of 5010 residents aged 60 to 70 years old from 100 villages and 20 communities in Renqiu city were selected by cluster random sampling. The subjects were divided into MS group and non-MS group. Serum lipids, blood glucose, blood pressure, body mass index (BMI), waist circumference (WC) were measured in two groups. TG/HDL-C. was calculated. The optimum point of TG/HDL-C for MS prediction was obtained by using the test work curve (ROC). Results there was a significant difference in TG/HDL-C between MS group and non MS group [1.68 (1.22 卤2.48) vs 0.73 (0.52n 1.03)] (P0.05). According to the quartile of TG/HDL-C level, with the increase of TG/HDL-C level, the BMI,WC, waist body index (WHtR) and (UA), insulin (INS),) insulin resistance (HOMA-IR) between male and female groups increased gradually, and the female fasting blood glucose (FPG) increased gradually. The HDL-C of male and female groups decreased gradually (P0.05) .ROC analysis showed that the diagnostic efficiency of MS was the highest when the TG/HDL-C cut value was 1.11 in the elderly male population, the area under the curve was 0.873 [Pu 0.0000.95% CI (0.854 卤0.892)], the sensitivity was 79.3%, the specificity was 83.8%; in the elderly female population, when the TG/HDL-C cut value was 1.19, the sensitivity was 79.3%, and the specificity was 83.8%. The diagnostic efficiency of MS was the highest, the area under the curve was 0.846 [0.000 ~ 9595 CI (0.831 ~ 0.861)], the sensitivity was 77.7%, the specificity was 81.1%. Conclusion TG/HDL-C is closely related to MS, which is important for early prediction and prevention of MS in the elderly.
【作者单位】：任丘康济医院;首都医科大学附属天坛医院;
【基金】：河北省科技支撑计划项目(12276104D-90)
【分类号】：R589

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