性激素结合球蛋白和胰岛β细胞分泌功能的相关性研究

发布时间：2018-09-05 14:58

【摘要】：目的观察健康人群中血清性激素结合球蛋白(SHBG)水平和胰岛β细胞分泌功能的关系,探讨可能的机制。方法选取门诊体检糖耐量正常(NGT)者30名,检测血清SHBG水平、HbA_1c、血脂谱、肝肾功能等生化指标。行OGTT+胰岛素释放试验,评估胰岛β细胞功能(HOMA-β)、早期相胰岛素分泌功能和晚期相胰岛素分泌功能。结果平均SHBG为(115.4l±59.37)nmol/L,校正性别、年龄后,NGT者SHBG与胰岛β细胞早期相分泌功能(r=-0.40,P=0.028)、晚期相分泌功能(r=-0.39,P=0.033)呈负相关;与HOMA-β无相关性(r=-0.28,P=0.131)。校正HOMA-IR后,早期相胰岛素分泌功能和晚期相胰岛素分泌功能与SHBG无相关性(r=-0.26,P=0.172;r=-0.24,P=0.214)。以SHBG为因变量,以HOMA-β、早期相胰岛素分泌功能、晚期相胰岛素分泌功能和HOMA-IR为自变量,行多元回归分析,结果显示,各项指标均非SHBG的影响因素(P0.05)。结论在NGT人群中,SHBG与胰岛β细胞分泌功能相关,但这一相关性可能是继发于IR。
[Abstract]:Objective to investigate the relationship between the level of serum sex hormone binding globulin (SHBG) and the secretion function of islet 尾 cells in healthy population and to explore the possible mechanism. Methods 30 patients with normal glucose tolerance (NGT) were selected for outpatient examination. The serum SHBG level, serum HbA1c, blood lipid profile, liver and kidney function and other biochemical indexes were detected. OGTT insulin release test was performed to evaluate the islet 尾 cell function (HOMA- 尾), insulin secretion in the early phase and insulin secretion in the late phase. Results the average SHBG was (115.41 卤59.37) nmol/L, adjusted for sex. After age, SHBG was negatively correlated with 尾 -cell secretory function in early phase (r-0.40), but negatively correlated with that of HOMA- 尾 in late phase (r-0.39) P0.033 (r-0.28 P0. 131). After adjusting for HOMA-IR, there was no correlation between the insulin secretion in early phase and late phase and SHBG (r-0.26 ~ 0.172 ~ 0.24 ~ 0.24 ~ 0.214). With SHBG as dependent variable, HOMA- 尾, early phase insulin secretion function, late phase insulin secretion function and HOMA-IR as independent variables, multiple regression analysis was carried out. The results showed that each index was not the influencing factor of SHBG (P0.05). Conclusion SHBG is associated with islet 尾 cell secretory function in NGT population, but this correlation may be secondary to IR..
【作者单位】：复旦大学附属闵行医院内分泌代谢科;
【基金】：上海市科委资助课题(15411970700) 闵行区中心医院基础资助课题(2016MHJC03)
【分类号】：R587.1

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