HSPB1（HSP27）表达水平与糖尿病病变程度相关性研究

发布时间：2018-09-11 16:40

【摘要】：目的:糖尿病是最常见的慢性病之一,流行率正逐渐上升。目前糖尿病的发病机制尚不明确。高血糖状态引起的氧化应激增加是引起胰岛细胞损伤及糖尿病并发症靶器官损害的重要机制。氧化反应亢进会引起细胞凋亡,而热休克蛋白基因HSPB1表达的HSP27蛋白是近期发现的介导细胞凋亡的相关分子。我们的目的是调查正常葡萄糖耐量(NGT),葡萄糖耐量异常(IGT)和2型糖尿病患者与HSP27表达水平有无相关性。方法:入选从2015年10月至2016年12月之间于宁夏医科大学总医院及心脑血管病医院就诊的2型糖尿病患者36例,糖耐量异常患者28例,及同期健康体检患者22例,并且匹配年龄和性别。收集研究对象资料,包括性别、年龄、体重指数、病程、血压、空腹血糖(FBG)、血脂、糖化血红蛋白、糖尿病组病程等。且通过ELISA法测量每个研究对象HSP27的水平做统计学分析。结果:糖尿病组HSP27水平(299.33+58.92pg/ml)显着低于IGT患者(347.46+66.24pg/ml,P0.05),高于正常对照组(211.86+70.08pg/ml,P0.05)。结论:1.人血清HSP27的表达水平与糖尿病及糖尿病发展程度有关。2.HbA1c与HSP27水平存在相关性。
[Abstract]:Objective: diabetes is one of the most common chronic diseases and the prevalence rate is increasing gradually. At present, the pathogenesis of diabetes is not clear. The increase of oxidative stress induced by hyperglycemia is an important mechanism of islet cell injury and diabetic complication target organ damage. Hyperoxidation can induce apoptosis, and the HSP27 protein expressed by heat shock protein gene (HSPB1) is a recently discovered molecule involved in cell apoptosis. Our aim was to investigate the correlation between normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (type 2 diabetes mellitus) with HSP27 expression. Methods: from October 2015 to December 2016, 36 patients with type 2 diabetes mellitus, 28 patients with impaired glucose tolerance and 22 patients with physical examination were enrolled from the General Hospital of Ningxia Medical University and the Hospital for Cardiovascular and Cerebrovascular Diseases. And match age and gender. Data were collected, including sex, age, body mass index, course of disease, blood pressure, fasting blood glucose, (FBG), glycosylated hemoglobin, course of diabetes. The level of HSP27 was measured by ELISA method. Results: the level of HSP27 in diabetic group (299.33 58.92pg/ml) was significantly lower than that in IGT group (347.46 66.24 PG / ml P 0.05) and higher than that in normal control group (211.86 70.08 PG / ml P 0.05). Conclusion 1. The expression of HSP27 in human serum was related to the degree of diabetes mellitus and the development of diabetes mellitus. 2. HbA1c was correlated with the level of HSP27.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1

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