新疆哈萨克族成人代谢综合征筛检指标评价

发布时间：2018-09-11 18:36

【摘要】：目的比较人体测量及反映动脉粥样硬化的相关指标对新疆哈萨克族成人代谢综合征(MS)的筛检能力。方法采用整群随机抽样的方法,对伊犁新源县年龄18周岁的哈萨克族常住居民进行问卷调查、体格检查和血生化检测,调查人群3450人,分别应用国际糖尿病联盟(IDF)、多机构联合声明(JIS)及《中国成人血脂异常防治指南》制定联合委员会(JCDCG)标准诊断MS。结果按照IDF、JIS及JCDCG标准,哈萨克族成人MS年龄标化患病率分别为18.3%、22.0%、17.3%。按照IDF标准,腰围身高比(WHtR)筛检男女性MS的受试者工作特征(ROC)曲线下面积(AUC)最大,分别为0.872、0.804,适宜切点值分别为0.53、0.52,其次是脂质蓄积指数(LAP),AUC分别为0.858、0.801,适宜切点值分别为34.8、26.5,两者AUC差异无统计学意义(P0.05);按照JIS及JCDCG标准,LAP筛检男女性MS的ROC AUC最大,其中男性分别为0.816、0.858,适宜切点值均为34.8,女性分别为0.788、0.832,适宜切点值为26.5、28.3;以IDF为金标准,WHtR、LAP并联及串联筛检男性MS的约登指数分别为0.608、0.591,女性分别为0.479、0.445。结论 WHtR及LAP均是筛检哈萨克族MS的优秀指标,其并联筛检MS的真实性最好。
[Abstract]:Objective to compare the screening ability of anthropometric and atherosclerosis related indexes for (MS) of Kazak adults in Xinjiang. Methods A total of 3450 Kazakh residents aged 18 years old in Xinyuan County of Yili were investigated by questionnaire, physical examination and blood biochemistry test by cluster random sampling. The International Diabetes Federation (IDF), Multi-agency Joint statement (JIS) and the Chinese guidelines for the Prevention and treatment of Adult dyslipidemia were used to establish the Joint Committee (JCDCG) criteria for the diagnosis of MS.. Results according to IDF,JIS and JCDCG standards, the age-standardized prevalence of MS in Kazakh adults was 18.32.0 and 17.30.The prevalence rate of MS in Kazakh adults was 17.30.Results the age standardized prevalence of MS in Kazakh adults was 18.30.22. According to IDF criteria, the area under the (ROC) curve was the largest in subjects with waist circumference / height ratio (WHtR) screening for male and female MS. The optimum cut point value was 0.53n 0.52, followed by the lipid accumulation index (LAP) 0.801 and the suitable point value (34.826.5). There was no significant difference in AUC between the two groups (P0.05), and the ROC AUC of male and female MS was the largest in accordance with JIS and JCDCG standard lap screening, and the difference between the two groups was not significant (P0.05), and the difference between the two groups was not significant (P 0.05), and the difference between the two groups was not statistically significant (P0.05), and the ROC AUC of male and female MS was the largest according to JIS and JCDCG standard. Among them, the values of suitable point of cut were 0.816 / 0.858 for males and 34.8for females, respectively, and for females were 0.788and 0.832, respectively, and for IDF as gold standard, the Jolden index of MS for parallel connection and series screening was 0.6080.591and 0.4790.445respectively. Conclusion both WHtR and LAP are excellent indexes for screening Kazakh MS, and their parallel screening MS is the best.
【作者单位】：石河子大学医学院预防医学系;
【基金】：国家公益性行业基金项目(201402002) 国家自然科学基金(81560551)
【分类号】：R589

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