超声引导下三种介入方法治疗甲状腺囊性结节效果比较

发布时间：2018-10-08 09:05

【摘要】：目的比较超声引导下~(32)P磷酸铬胶体(简称~(32)P)胶体、无水酒精及单纯抽液介入治疗甲状腺囊性结节的临床效果,探讨最佳介入治疗方法。方法将189例甲状腺囊性结节患者随机分为~(32)P胶体组71例、无水酒精组65例、单纯抽液组53例。三组均于超声引导下抽尽囊液,~(32)P胶体组注入~(32)P胶体1.85~3.70 MBq/cm3与地塞米松1~5 mg的混合液;无水酒精组按抽液量的1/3注入无水酒精;单纯抽液组不注入药物。比较三组的临床疗效、不良反应发生率及二次治疗率。结果~(32)P胶体组、无水酒精组、单纯抽液组首次治疗有效率分别为87.32%(62/71)、70.77%(46/65)、22.64%(12/53)。~(32)P胶体组首次治疗有效率高于无水酒精组和单纯抽液组(P0.05或0.01),且无水酒精组高于单纯抽液组(P0.01)。~(32)P胶体组、无水酒精组、单纯抽液组不良反应发生率分别为4.2%(3/71)、10.8%(7/65)、3.8%(2/53)。三组不良反应发生率比较,P均0.05。~(32)P胶体组、无水酒精组、单纯抽液组分别有29例(40.8%)、46例(70.8%)、51例(96.2%),需进行二次治疗,其二次治疗率依次升高(P均0.01)。结论超声引导下~(32)P胶体介入治疗甲状腺囊性结节临床效果较好、安全性较高。
[Abstract]:Objective to compare the clinical effects of ultrasound guided ~ (32) P chromic phosphate colloid (32) P) colloid), anhydrous alcohol and simple extraction in the treatment of thyroid cystic nodules, and to explore the best interventional therapy. Methods 189 patients with thyroid cystic nodules were randomly divided into ~ (32) P colloid group (n = 71), anhydrous alcohol group (n = 65) and simple extraction group (n = 53). All the three groups were injected with ~ (32) P colloidal solution (1.85 ~ 3.70 MBq/cm3) and dexamethasone (1 ~ 5 mg) under the guidance of ultrasound, the anhydrous alcohol group was injected with anhydrous alcohol according to 1 / 3 of the extracted volume, and the pure extract group was not injected with drugs. The clinical efficacy, adverse reaction rate and secondary treatment rate were compared among the three groups. Results the effective rates of the first treatment were 87.32% (62 / 71), 70.77% (46 / 65), 22.64% (12 / 53) .32 P colloidal group were higher than those in the anhydrous alcohol group and the pure extraction group (P0.05 or 0.01), and the effective rate of the absolute alcohol group was higher than that of the pure extract group (P0.01) .32 P colloid group. In anhydrous alcohol group, the incidence of adverse reactions was 4.2% (3 / 71) or 10.8% (7 / 65) or 3.8% (2 / 53) respectively. There were 29 cases (40.8%) and 46 cases (70.8%) with 51 cases (96.2%) in the three groups, respectively. The rate of secondary treatment was higher than that of the control group (P 0.01), and the incidence of adverse reactions was 0.05.32 P colloidal group, anhydrous alcohol group and pure liquid extraction group respectively (29 cases, 40.8%, 70.8%, 96.2%), and the rate of secondary treatment was higher than that of the control group (P 0.01). Conclusion Ultrasound-guided ~ (32) P colloid interventional therapy for thyroid cystic nodules is effective and safe.
【作者单位】：河北工程大学附属医院;
【分类号】：R581

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