新疆维吾尔族甲状腺结节患病率及其影响因素研究

发布时间：2018-10-08 18:58

【摘要】：目的了解新疆维吾尔族甲状腺结节患病率,并探讨其影响因素。方法于2015年9—12月,采用分层整群随机抽样方法,选取新疆乌鲁木齐市天山区18~80岁的居民为调查对象。发放流行病学调查表,调查内容包括一般情况、甲状腺疾病史及家族史,饮食及生活习惯;体格检查检测血压、身高、体质量、腰围,计算体质指数(BMI);采集空腹静脉血及晨尿,检测血糖、血脂、尿酸、糖化血红蛋白、尿碘等;采用甲状腺超声检查确诊甲状腺结节。采用单因素及多因素Logistic回归分析甲状腺结节患病的影响因素。结果纳入1 500例,共1 268例完成调查,实际调查率为84.53%。调查对象甲状腺结节粗患病率为27.21%(345/1 268),男性粗患病率为20.49%(118/576),女性粗患病率为32.80%(227/692)。女性甲状腺结节患病率高于男性(χ~2=24.080,P0.01)。18~29、30~39、40~49、50~59、60~80岁甲状腺结节患病率分别为14.55%(55/378)、16.07%(45/280)、29.93%(88/294)、45.15%(93/206)、58.18%(64/110),随着年龄的增长,甲状腺结节患病率逐渐升高(χ_(趋势)~2=126.591,P0.01)。单因素Logistie回归分析结果显示,女性(OR=1.895)、年龄(OR=1.056)、轻度进食盐习惯(OR=1.697)、吸烟史(OR=1.431)、甲状腺功能减退(OR=1.555)、甲状腺肿(OR=6.351)、糖尿病(OR=2.481)、高血压(OR=2.925)、血脂异常(OR=1.928)、BMI为24.0~27.9 kg/m~2(OR=1.542)和≥28.0 kg/m~2(OR=2.721)、腰围(OR=2.639)、空腹血糖(FPG)(OR=2.645)、口服葡萄糖耐量试验(OGTF)2 h血糖(OR=2.542)、收缩压(OR=3.180)、舒张压(OR=2.928)、三酰甘油(TG)(OR=1.586)、总胆固醇(TC)(OR=1.714)、低密度脂蛋白(LDL)(OR=1.684)、糖化血红蛋白(OR=1.864)、促甲状腺激素(TSH)4.20 mU/L(OR=1.554)、甲状腺过氧化物酶抗体(TPOAb)(OR=1.479)、甲状腺球蛋白抗体(TGAb)(OR=1.581)是甲状腺结节的影响因素(P0.05)。多因素Logistic回归分析结果显示,性别(OR=2.044)、年龄(OR=1.046)和收缩压(OR=2.638)是甲状腺结节的独立影响因素(P0.05)。结论新疆维吾尔族甲状腺结节患病率较高,危险因素较多,尤其是对于女性、高龄、高血压患者,应做到早预防、早诊断、早治疗。
[Abstract]:Objective to investigate the prevalence of thyroid nodule in Uygur nationality of Xinjiang and its influencing factors. Methods from September to December, 2015, stratified cluster random sampling was used to select 1880 years old residents of Tianshan District, Urumqi, Xinjiang. An epidemiological questionnaire was issued, which included general information, history of thyroid diseases and family history, diet and lifestyle, physical examination, blood pressure, height, body mass, waist circumference, fasting venous blood and morning urine collected by calculating body mass index (BMI);). Blood glucose, blood lipids, uric acid, glycosylated hemoglobin, urine iodine, etc. Thyroid nodules were diagnosed by thyroid ultrasound. Univariate and multivariate Logistic regression analysis was used to analyze the risk factors of thyroid nodules. Results 1 500 cases were included and 1 268 cases completed the investigation. The actual investigation rate was 84.53. The crude prevalence rate of thyroid nodule was 27.21% (345 / 1 268), that of male was 20.49% (118 / 576) and that of female was 32.80% (227 / 692). The prevalence rate of thyroid nodule in female was higher than that in male (蠂 ~ 2 / 2 / 24.080 / P0.01). The prevalence rate of thyroid nodule was 14.55% (55 / 378) 16.07% (45 / 280) / 29.93% (% / 88294) and 58.18% (93.206) / (64 / 110) respectively. The prevalence rate of thyroid nodule increased with age (蠂 _ (trend) 2126.591P _ (0.01). Univariate Logistie regression analysis showed that, 濂虫，

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