骨转换标志物在糖尿病中的研究进展

发布时间：2018-10-11 19:14

【摘要】：随着糖尿病和骨质疏松症在我国的广泛流行,糖尿病性骨质疏松症已成为糖尿病患者致死、致残的重要原因,严重影响患者的生活质量,并给个人、社会带来沉重负担。1型糖尿病患者骨密度降低,骨折风险增加;2型糖尿病患者骨密度常增高或正常,但骨折风险也是增加的,这不能仅靠双能X线骨密度来解释。骨转换标志物具有灵敏度高、特异性强、稳定性好等优点,近年来在糖尿病中得到广泛研究,如骨碱性磷酸酶、1型原胶原N-端前肽、1型胶原交联C-末端肽、骨钙素、骨保护素、脱氧吡啶啉等。骨转换标志物反映骨吸收和骨形成的具体变化情况,反映骨强度,较骨密度更早的反映骨量变化,大量临床研究发现,它为临床早期发现和诊断糖尿病性骨质疏松症,评估糖尿病患者骨折风险提供了新思路。联合检测骨转换标志物和骨密度,更全面、合理的评估骨转换,及时发现高危人群,更有利于糖尿病性骨质疏松症患者的早期诊断及治疗,预防骨折的发生。本文将对骨转换标志物在糖尿病中的研究进展作一综述。
[Abstract]:With the prevalence of diabetes and osteoporosis in our country, diabetic osteoporosis has become an important cause of death and disability in patients with diabetes, seriously affecting the quality of life of patients and giving it to individuals. Society brings a heavy burden. Type 1 diabetes patients have lower bone density and higher fracture risk. Type 2 diabetes patients often have higher or normal bone mineral density, but the fracture risk is also increased, which can not be explained by dual energy X-ray bone mineral density alone. Bone conversion markers have been widely studied in recent years, such as bone alkaline phosphatase, type 1 procollagen N-terminal prepeptide, type 1 collagen cross-linked C-terminal peptide, osteocalcin, osteoprotegerin, and so on. Deoxypyridine, etc. Bone turnover markers reflect specific changes of bone resorption and bone formation, reflect bone strength, and reflect bone mass changes earlier than bone mineral density. A large number of clinical studies have found that it is an early clinical diagnosis of diabetic osteoporosis. The evaluation of fracture risk in diabetic patients provides a new idea. Combined detection of bone turnover markers and bone mineral density, more comprehensive and reasonable evaluation of bone turnover, timely detection of high-risk population, is more conducive to the early diagnosis and treatment of patients with diabetic osteoporosis, and to prevent the occurrence of fractures. This article reviews the progress of bone turnover markers in diabetes mellitus.
【作者单位】：南京医科大学第一附属医院内分泌科;
【分类号】：R587.1;R580

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