启宫丸方对多囊卵巢综合征伴不孕症患者子宫动脉血流和内膜容受性的影响

发布时间：2018-10-12 18:04

【摘要】：目的:探讨启宫丸方辅助治疗对多囊卵巢综合征(PCOS)伴不孕症患者的子宫动脉血流和内膜容受性的影响。方法:选择2016年1-12月到我院就诊的86例PCOS伴不孕症患者,采用随机数字表法分为对照组和观察组,各43例。对照组患者采取化学药长方案垂体降调节治疗;观察组患者在对照组基础上给予启宫丸方辅助治疗,每日1剂,以水煎成400 m L,分早晚2次温服,用药至行人工受精术停止。比较两组患者治疗前和治疗后3个月的子宫超声指标和子宫内膜容受性,记录患者排卵、受孕以及不良反应发生情况。结果:治疗前,两组患者的子宫超声指标和内膜容受性指标比较,差异均无统计学意义(P0.05)。治疗后3个月,两组患者的子宫内膜厚度明显增大,子宫内膜螺旋动脉搏动指数和阻力指数明显减小,整合素αvβ_3和葡萄糖转运体4(GLUT4)的阳性表达水平明显升高,且观察组均明显优于对照组,差异均有统计学意义(P0.05);观察组患者的排卵率为83.72%,明显高于对照组的62.79%,差异有统计学意义(P0.05);两组患者受孕率比较(27.91%vs.18.60%),差异无统计学意义(P0.05)。两组患者均未见明显的不良反应发生。结论:启宫丸方辅助治疗有助于调节PCOS伴不孕症患者的子宫动脉血流动力学参数,增强子宫内膜容受性,从而提高排卵率。
[Abstract]:Objective: to investigate the effect of Qigong Pill on uterine artery blood flow and endometrial receptivity in patients with polycystic ovary syndrome (PCOS) with infertility. Methods: 86 PCOS patients with infertility from January to December 2016 were randomly divided into control group (n = 43) and observation group (n = 43). The patients in the control group were treated with pituitary hypophysis regulation and the patients in the observation group were treated with Qigong Pill on the basis of the control group. The patients in the observation group were treated with Qigong Pill, once a day, with water decoction of 400 mL, taken warm orally in the morning and evening, until the artificial insemination was stopped. The ultrasound parameters and endometrial receptivity before and after treatment were compared between the two groups. Ovulation, pregnancy and adverse reactions were recorded. Results: before treatment, there was no significant difference in uterine ultrasound and endometrial receptivity between the two groups (P0.05). Three months after treatment, the endometrial thickness increased, the pulsatility index and resistance index of endometrial spiral artery decreased, and the positive expression of integrin 伪 v 尾 _ 3 and glucose transporter 4 (GLUT4) increased significantly. The observation group was significantly better than the control group, the difference was statistically significant (P0.05); the ovulation rate of the observation group was 83.722, significantly higher than that of the control group (P 0.05); the pregnancy rate of the two groups (27.91 vs 18.60%), the difference was not statistically significant (P0.05). No significant adverse reactions occurred in both groups. Conclusion: Qigong Pill adjuvant therapy can regulate uterine artery hemodynamic parameters of PCOS patients with infertility, enhance endometrial receptivity and increase ovulation rate.
【作者单位】：北华大学附属医院药学部;北华大学附属医院生殖医学中心;
【分类号】：R711.6;R711.75

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