Hcy对行体外受精-胚胎移植治疗PCOS患者卵子质量及发育潜能的影响

发布时间：2018-10-17 10:15

【摘要】：目的探究同型半胱氨酸(Hcy)对行体外受精-胚胎移植治疗多囊卵巢综合征(PCOS)患者卵子质量及发育潜能影响。方法行体外受精-胚胎移植治疗PCOS患者70例为研究组,另选同期因输卵管因素行体外受精-胚胎移植治疗不孕患者69例为对照组,比较2组取卵日血浆、卵泡液Hcy浓度,统计2组卵子质量及发育潜能,分析Hcy浓度与优质胚胎率、卵裂率、受精率相关性。结果研究组取卵日血浆、卵泡液Hcy浓度均明显高于对照组(P0.05);卵子成熟率、卵子回收率、优质胚胎率、卵裂率、受精率均显著低于对照组(P0.05);Hcy浓度与优质胚胎率、卵裂率、受精率均呈明显负相关(P0.05)。结论 PCOS患者血浆、卵泡液Hcy浓度显著升高,是导致卵子质量及发育潜能较低重要原因。
[Abstract]:Objective to investigate the effect of homocysteine (Hcy) on egg quality and developmental potential in patients with polycystic ovary syndrome (PCOS) treated by in vitro fertilization and embryo transfer. Methods 70 patients with PCOS treated by in vitro fertilization and embryo transfer were selected as study group and 69 infertile women who were treated with in vitro fertilization and embryo transfer for tubal factor as control group. The concentration of Hcy in plasma and follicular fluid was compared between the two groups on the day of egg collection. The quality and developmental potential of eggs in two groups were counted and the correlation between Hcy concentration and high quality embryo rate, cleavage rate and fertilization rate was analyzed. Results the concentration of Hcy in plasma and follicular fluid in the study group was significantly higher than that in the control group (P0.05), and the maturation rate, recovery rate, high quality embryo rate, cleavage rate and fertilization rate of the study group were significantly lower than those of the control group (P0.05). The fertilization rate was negatively correlated (P0.05). Conclusion the concentration of Hcy in plasma and follicular fluid of patients with PCOS is significantly increased, which is an important reason for lower egg quality and developmental potential.
【作者单位】：海南省妇幼保健院生殖医学中心;
【基金】：海南省卫生厅科研计划项目(琼卫重点2015-44)
【分类号】：R711.75;R714.8

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