抗SSA抗体阳性患者临床及神经影像学分析

发布时间：2018-10-18 10:27

【摘要】：目的:探讨抗SSA抗体阳性患者的临床特点及神经影像学特征,提高医生对该抗体临床意义的认识。方法:对我院2015年3月15日至2016年1月15日抗SSA抗体阳性患者的临床资料进行回顾性分析。结果:共308例抗SSA抗体阳性患者,其中男77例,女231例,男女1∶3。35~50岁组构成比高于其它组;系统性红斑狼疮患者有106例(34.42%),干燥综合征患者有52例(16.88%),类风湿性关节炎患者有10例(3.25%),视神经脊髓炎患者有7例(2.27%);50例行影像学检查中10例正常,26例白质变性,9例缺血样改变,5例颈髓病变。54例患者合并神经系统损害。结论:抗SSA抗体阳性不能与干燥综合征划上等号。抗SSA抗体阳性患者更易合并神经系统损害,包括中枢性(脑、脊髓)损害及周围性(周围神经、肌肉)损害,神经影像学表现以皮层下白质及室旁白质病变为主。
[Abstract]:Objective: to investigate the clinical and neuroimaging features of anti-SSA antibody positive patients and to improve their understanding of the clinical significance of anti-SSA antibody. Methods: the clinical data of anti-SSA antibody positive patients in our hospital from March 15, 2015 to January 15, 2016 were retrospectively analyzed. Results: a total of 308 patients (77 males and 231 females) were positive for anti SSA antibody. The composition ratio of male and female 1: 3.35 + 50 years old group was higher than that of other groups. 106 cases (34.42%) of systemic lupus erythematosus, 52 cases (16.88%) of Sjogren's syndrome, 10 cases (3.25%) of rheumatoid arthritis, 7 cases (2.27%) of optic neuromyelitis, 10 cases of normal, 26 cases of white matter degeneration and 9 cases of deficiency in 50 cases of imaging examination. There were 5 cases of cervical spinal cord lesion and 54 cases of nervous system damage. Conclusion: anti-SSA antibody can not be equated with Sjogren's syndrome. Patients with anti SSA antibody were more likely to be complicated with nervous system damage, including central (brain, spinal cord) damage and peripheral (peripheral nerve, muscle) damage. The neuroimaging manifestations were mainly subcortical white matter and ventricular paracentricular white matter lesions.
【作者单位】：南方医科大学南方医院神经内科;
【基金】：南方医院院长基金(3101030102)
【分类号】：R593.2

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