糖尿病患者MCI患病情况调查及相关危险因素分析
发布时间：2018-10-19 11:33
【摘要】：背景糖尿病在中国已呈现流行趋势,糖尿病的慢性并发症对患者、家庭、社会造成大量的负担。糖尿病轻度认知功能障碍(mild cognition impairment,MCI)也是其慢性并发症之一。其作为痴呆的早期阶段如果能给予有效的干预可延缓其发生。有很多因素可导致糖尿病MCI发生,了解其中相关危险因素,对干预及延缓糖尿病MCI的发展有重要的意义。目的了解2型糖尿病患者的认知功能及轻度认知功能障碍的患病现状,探讨糖尿病轻度认知功能障碍发生的相关因素。方法本研究自2014年10月至2015年12月共收集样本95例,其中67例糖尿病组为就诊于常熟市第二人民医院内分泌科和苏州大学附属第二医院内分泌科的确诊为2型糖尿病的患者,其中男性34例,女性33例,平均年龄为64.1±9.2岁。对照组28例为就诊于常熟市第二人民医院老干部病区的非糖尿病人群,其中男性15例,女性13例,平均年龄为60.8±8.5岁。利用蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评定患者的认知功能,统计收集的各种变量,数据由SPSS 13.0软件进行处理,两者之间的分类资料采用Χ2检验,两组之间计量资料的比较采用独立t检验,相关因素采用Logistic回归分析。结果糖尿病组的MoCA评分低于对照组,MoCA以26分为诊断轻度认知功能障碍的界值时,糖尿病组的MCI发生率(77.6%)显著高于对照组(39.3%),差异具有统计学意义(P0.001)。单因素logistic回归显示,糖尿病与MCI为正相关(OR=5.358,95%CI:2.069-13.873,P=0.001),年龄(≤60岁)与MCI为负相关(OR=0.300,95%CI=0.124-0.728,P=0.008)、文化程度(小学及以下)与MCI正相关(OR=57.773,95%CI:7.381-452.193,P0.0001)、颈动脉斑块与MCI为正相关(OR=3.786,95%CI:1.38-12.592,P=0.03)。糖尿病轻度认知功能障碍组(MCI组)与糖尿病正常组(NC组)在进行多因素logistic回归分析显示空腹血糖的控制(≥7mmol/l)与糖尿病MCI发生为正相关(OR=8.425,95%CI=1.133-62.626,P=0.037),文化程度(小学及以下)与糖尿病MCI发生为正相关(OR=24.468,95%CI=2.468-242.6,P=0.006)。结论1.2型糖尿病患者发生轻度认知障碍风险明显升高,2型糖尿病是轻度认知功能障碍发生的危险因素。2.2型糖尿病患者拥有高文化程度为糖尿病MCI的保护因素,糖尿病患者空腹血糖水平控制不佳为糖尿病MCI发生的独立危险因素。
[Abstract]:Background Diabetes mellitus has been prevalent in China. The chronic complications of diabetes cause a great deal of burden to patients, families and society. Diabetes mellitus with mild cognitive impairment (mild cognition impairment,MCI) is also one of its chronic complications. As an early stage of dementia, it can be delayed if effective intervention is given. There are many factors leading to the development of diabetic MCI. It is important to understand the related risk factors and to intervene and delay the development of diabetic MCI. Objective to investigate the cognitive function of type 2 diabetes mellitus (DM) and the prevalence of mild cognitive dysfunction (MCI), and to explore the related factors of MCI in type 2 diabetes mellitus (DM). Methods from October 2014 to December 2015, a total of 95 patients with type 2 diabetes were collected. Among them, 67 patients with diabetes mellitus were diagnosed as type 2 diabetes in the Endocrinology Department of the second people's Hospital of Changshu City and the Endocrinology Department of the second affiliated Hospital of Suzhou University. There were 34 males and 33 females with an average age of 64.1 卤9.2 years. The control group (n = 28) was a non-diabetic group, including 15 males and 13 females, with an average age of 60.8 卤8.5 years. The cognitive function of patients was assessed by Montreal Cognitive Assessment scale (Montreal Cognitive Assessment,MoCA). The data collected were processed by SPSS 13.0 software. The classified data between them were tested by X 2 test. The measurement data of the two groups were compared by independent t test, and the related factors were analyzed by Logistic regression analysis. Results the MoCA score in the diabetic group was lower than that in the control group. The incidence of MCI in the diabetic group (77.6%) was significantly higher than that in the control group (39.3%) when MoCA was classified as the threshold value for the diagnosis of mild cognitive impairment (P0.001). The difference was statistically significant (P0.001). Univariate logistic regression showed that diabetes mellitus was positively correlated with MCI (OR=5.358,95%CI:2.069-13.873,P=0.001), age (鈮，
本文编号：2280992
[Abstract]:Background Diabetes mellitus has been prevalent in China. The chronic complications of diabetes cause a great deal of burden to patients, families and society. Diabetes mellitus with mild cognitive impairment (mild cognition impairment,MCI) is also one of its chronic complications. As an early stage of dementia, it can be delayed if effective intervention is given. There are many factors leading to the development of diabetic MCI. It is important to understand the related risk factors and to intervene and delay the development of diabetic MCI. Objective to investigate the cognitive function of type 2 diabetes mellitus (DM) and the prevalence of mild cognitive dysfunction (MCI), and to explore the related factors of MCI in type 2 diabetes mellitus (DM). Methods from October 2014 to December 2015, a total of 95 patients with type 2 diabetes were collected. Among them, 67 patients with diabetes mellitus were diagnosed as type 2 diabetes in the Endocrinology Department of the second people's Hospital of Changshu City and the Endocrinology Department of the second affiliated Hospital of Suzhou University. There were 34 males and 33 females with an average age of 64.1 卤9.2 years. The control group (n = 28) was a non-diabetic group, including 15 males and 13 females, with an average age of 60.8 卤8.5 years. The cognitive function of patients was assessed by Montreal Cognitive Assessment scale (Montreal Cognitive Assessment,MoCA). The data collected were processed by SPSS 13.0 software. The classified data between them were tested by X 2 test. The measurement data of the two groups were compared by independent t test, and the related factors were analyzed by Logistic regression analysis. Results the MoCA score in the diabetic group was lower than that in the control group. The incidence of MCI in the diabetic group (77.6%) was significantly higher than that in the control group (39.3%) when MoCA was classified as the threshold value for the diagnosis of mild cognitive impairment (P0.001). The difference was statistically significant (P0.001). Univariate logistic regression showed that diabetes mellitus was positively correlated with MCI (OR=5.358,95%CI:2.069-13.873,P=0.001), age (鈮，
本文编号：2280992
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