加味四妙丸联合西药治疗急性痛风性关节炎28例临床研究

发布时间：2018-10-19 13:21

【摘要】：目的评价加味四妙丸治疗急性痛风性关节炎(AGA)的临床疗效。方法选取AGA患者60例,随机分为西药组和中西药组各30例。西药组予双氯芬酸钠缓释片口服,每次75 mg,每日1次;碳酸氢钠片口服,每次1000 mg,每日3次。中西药组在西药组基础上联合加味四妙丸。两组均治疗3天,治疗期间患者如因关节疼痛加重经评定改用糖皮质激素治疗。分别于治疗前后检测患者血白细胞(WBC)、C反应蛋白(CRP)、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、血尿酸(UA)、血肌酐(Cr)水平,并进行关节疼痛评分和关节红肿评分。比较两组患者改用糖皮质激素的比例。结果中西药组改用糖皮质激素治疗2例,明显低于西药组的9例(P0.05);中西药组治疗后WBC、CRP、UA水平及关节疼痛评分、关节红肿评分均较治疗前明显降低(P0.01),且CRP、UA水平及关节疼痛评分、关节红肿评分均低于西药组(P0.05)。结论加味四妙丸治疗AGA可抑制炎症反应,缓解关节肿痛症状,减少糖皮质激素使用。
[Abstract]:Objective to evaluate the clinical effect of Jiawei Simiao pill on acute gouty arthritis (AGA). Methods 60 patients with AGA were randomly divided into western medicine group (30 cases) and traditional Chinese medicine group (30 cases). The western medicine group was treated with diclofenac sodium sustained release tablet once a day for 75 mg, and sodium bicarbonate tablet 3 times a day for 1000 mg,. The Chinese and western medicine group combined with modified Simiao pills on the basis of western medicine group. Both groups were treated with glucocorticoid for 3 days. Before and after treatment, the levels of serum creatinine (Cr) (Cr) in patients with leukocyte (WBC), C reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine (Cr), joint pain score and joint redness were measured. The proportion of patients using glucocorticoid was compared between the two groups. Results two cases were treated with glucocorticoid in the Chinese and western medicine group, which were significantly lower than those in the western medicine group (P 0.05), the WBC,CRP,UA level, joint pain score and joint redness score were significantly lower in the Chinese and western medicine group than before treatment (P0.01), and the CRP,UA level and joint pain score were significantly lower in the Chinese and western medicine group than before treatment (P0.01). The score of joint redness and swelling was lower than that of western medicine group (P0.05). Conclusion Jiawei Simiao Pill can inhibit inflammation, relieve joint swelling and pain and reduce glucocorticoid use.
【作者单位】： 浙江中医药大学附属第一医院;浙江中医药大学基础医学院;
【基金】：浙江省中医药科技计划(2017ZB035)
【分类号】：R589.7
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本文编号：2281245