SLC22A12基因rs1529909和rs7929627位点多态性与高尿酸血症的相关性

发布时间：2018-10-23 10:51

【摘要】：目的探讨宁夏银川市居民SLC22A12基因rs1529909和rs7929627位点多态性与高尿酸血症的相关性。方法回顾性收集2014年4—11月在宁夏银川市某体检机构进行健康体检的365例确诊高尿酸血症患者资料,采用1∶1配对病例对照研究,按年龄(!5岁)、性别、民族进行匹配,选择同时间在该机构体检的365例血尿酸水平正常者作为对照。对研究对象进行问卷调查、体格检查、收集空腹静脉血进行生化检测和基因多态性检测。采用配对t检验进行两样本均数比较;条件Logistic回归分析高尿酸血症的影响因素;MDR软件分析两位点交互作用对高尿酸血症的影响。结果病例组体质指数、血尿酸、肌酐、总胆固醇、甘油三酯均值高于对照组(P0.05)。rs1529909位点等位基因频率在男性病例组与对照组之间的差异有统计学意义(χ~2=4.887,P=0.027);rs7929627位点各基因型频率在回族病例组和对照组中的差异有统计学意义(χ~2=14.906,P=0.002),在男性病例组和对照组中的差异有统计学意义(χ~2=9.749,P=0.021)。交互作用分析结果显示,高危与低危基因型在两组之间的分布有统计学意义(χ~2=8.338,P=0.004),高危基因型发生高尿酸血症的风险是低危基因型的1.536倍(OR=1.536,95%CI 1.147~2.057)。结论rs1529909位点和rs7929627位点与男性高尿酸血症的发生均有关联;rs7929627位点与回族高尿酸血症的发生有关;rs1529909与rs7929627位点对于高尿酸血症的影响可能存在明显的拮抗作用。
[Abstract]:Objective to investigate the association between rs1529909 and rs7929627 polymorphism of SLC22A12 gene and hyperuricemia in Yinchuan, Ningxia. Methods the data of 365 patients with hyperuricemia were collected retrospectively from April to November 2014 in a physical examination institution in Yinchuan, Ningxia, and matched by age (! 5 years), sex and nationality by 1:1 matched case-control study. 365 subjects with normal serum uric acid level were selected as control group. The subjects were investigated by questionnaire, physical examination, fasting venous blood and gene polymorphism. Paired t test was used to compare the mean of two samples; conditional Logistic regression analysis was used to analyze the influencing factors of hyperuricemia; and MDR software was used to analyze the effect of interaction between two loci on hyperuricemia. Results body mass index, serum uric acid, creatinine, total cholesterol, The mean value of triglyceride was higher than that of control group (P0.05). The allelic frequency of rs1529909 locus was significantly different between male and control group (蠂 ~ 24.887), and the frequency of rs7929627 locus genotypes was significantly different in Hui and control groups. There was a significant difference between male and control group (蠂 ~ 2 = 14.906, P = 0.002) (蠂 ~ 2 = 9.749, P = 0.021). The results of interaction analysis showed that the distribution of high risk genotype and low risk genotype was statistically significant between the two groups (蠂 ~ 2 ~ 2 = 8.338). The risk of hyperuricemia in high risk genotype was 1.536 times higher than that in low risk genotype (OR=1.536,95%CI 1.147 ~ 2.057). Conclusion both rs1529909 and rs7929627 loci are associated with the occurrence of hyperuricemia in males, rs7929627 loci are associated with the occurrence of hyperuricemia in Hui nationality, and the effects of rs1529909 and rs7929627 loci on hyperuricemia may have obvious antagonistic effects.
【作者单位】：宁夏医科大学公共卫生与管理学院流行病与卫生统计学系;
【基金】：宁夏高等学校科学技术研究项目(No.NGY2014087)
【分类号】：R589.7

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