艾滋病高效抗反转录病毒治疗5年免疫学效果评价

发布时间：2018-10-25 12:28

【摘要】：目的探讨艾滋病高效抗反转录病毒治疗(HAART)5年的免疫学疗效,为艾滋病的治疗提供依据。方法选择2010年1月-2016年5月在广西壮族自治区龙潭医院规律随诊、完成HAART满5年的145例患者,按CD_4细胞数将患者分为A、B、C三组,A组29例CD_4细胞数200个/μl,B组31例CD_4细胞数200~100个/μl,C组85例CD_4细胞数100个/μl;比较三组HAART后各年份的CD_4细胞数变化,对治疗后CD_4细胞数200个/μl、CD_4细胞数500个/μl的构成比进行统计分析。结果三组治疗后各年份的CD_4细胞数均显著增高,与基线比较差异有统计学意义(P0.05);A、B两组第3、4、5年CD_4细胞数组内比较,差异无统计学意义;C组第3、4、5年CD_4细胞数逐年增高,差异有统计学意义(P0.05);CD_4细胞增幅第1年最大,三组分别为150、111、157个/μl,显著高于组内其他时段改变(P0.05);5年间A组29例CD_4细胞数持续200个/μl,B、C两组CD_4200个/μl构成比逐年增高(P0.05),三组CD_4500个/μl的构成比逐渐增高(P0.05);治疗第5年,CD_4200个/μl的构成比A组为100.0%、B组93.55%、C组83.53%,CD_4500个/μl的构成比三组分别为65.52%、32.26%、27.06%。结论艾滋病5年HAART后,CD_4细胞数达到并维持在远高于治疗前的水平,但基线CD_4200个/μl的部分患者仍存在免疫重建不良,多数患者CD_4细胞数难以恢复到500个/μl,而基线CD_4200个/μl的患者半数以上CD_4细胞数恢复到正常水平;早期启动并维持长期抗病毒治疗可获得更好的免疫学疗效。
[Abstract]:Objective to investigate the 5-year immunological efficacy of anti-retroviral therapy for (HAART) and to provide evidence for the treatment of AIDS. Methods from January 2010 to May 2016, 145 patients with HAART in Longtan Hospital of Guangxi Zhuang Autonomous region were selected. According to the number of CD_4 cells, the patients were divided into three groups: group A (29 cases) with CD_4 cell count 200 / 渭 L B group (31 cases) with CD_4 cell count 200 ~ 100 / 渭 lC group (85 cases) with CD_4 cell number 100 / 渭 l, the changes of CD_4 cell number in each year after HAART were compared among the three groups. The composition ratio of 200 / 渭 L CD4 / 渭 l CD_4 cells was statistically analyzed. Results the number of CD_4 cells in each year after treatment in the three groups was significantly higher than that in the baseline group (P0.05), there was no significant difference in the number of CD_4 cells in the array of CD_4 cells in the 3rd and 5th years in group A and B, and the number of CD_4 cells in group C increased year by year at the 4th and 5th year after treatment. The difference was statistically significant (P0.05), the increase of CD_4 cells was the largest in the first year, During 5 years, the number of CD_4 cells in group A increased year by year (P0.05), the ratio of CD_4200 / 渭 l in two groups increased (P0.05), and the ratio of CD_4500 / 渭 l in three groups increased gradually (P0.05); in the 5th year, CD_4200 cells were found in group A (P 0.05), and in group A (P 0.05), the ratio of CD_4200 cells / 渭 l in group C was significantly higher than that in group A (P 0.05), and the ratio of CD_4200 / 渭 l in group C was significantly higher than that in group A (P 0.05). The composition ratio of CD4500 / 渭 l in group A was 100.0 and that in group C was 83.53. The proportion of CD4500 / 渭 l in group C was 65.52 and 32.262.27.06respectively. Conclusion after 5 years of HAART, the number of CD_4 cells reached and maintained much higher than that before treatment, but some patients with baseline CD_4200 / 渭 l still had poor immune reconstitution. The number of CD_4 cells in most patients was difficult to recover to 500 / 渭 l, but more than half of CD_4 cells in baseline patients with CD_4200 / 渭 l returned to normal level, and early initiation and maintenance of long-term antiviral therapy could obtain better immunological effect.
【作者单位】：广西壮族自治区龙潭医院;
【基金】：广西壮族自治区医疗卫生重点科研基金资助项目(重2010115) 广西壮族自治区卫生厅自筹经费科研基金资助项目(Z2010169)
【分类号】：R512.91

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