FURIN基因多态性与维吾尔族代谢综合征关联研究
发布时间：2018-10-30 20:24
【摘要】：目的：研究Furin基因功能多态性与维吾尔族代谢综合征的相关性。方法：以自然人群横断面调查为基础,选取1134例维吾尔族人(包括707例代谢综合征组和424例对照组)作为研究对象。从以往的研究中发现furin基因的4个代表性变异位点在本次研究对象中再次验证,并应用TaqMan-PCR在自然人群中进行基因型鉴定及病例对照研究。结果：Furin基因功能区的1个代表性变异位点rs2071410被验证成功,并发现rs2071410不同基因型在代谢综合征组和对照组中的分布有统计学差异(P=0.010) 等位基因分布在代谢综合征组与对照组中分布有统计学差异(P=0.546)。Logistic回归分析,校正混杂因素,如TNF-a、BMI、血脂、血压、血糖以及rs2071410后发现,TT基因型仍是代谢综合征独立的危险因素(p=0.013;OR=1.471,95% CI 1.297-1.761)。rs2071410不同基因型间TNF-a、空腹血糖、餐后2 h血糖、胰岛素抵抗指数、血LDL、收缩压等指标的均值差异均有统计学意义(P0.05)。结论：Furin基因变异与维吾尔族人代谢综合征可能相关,该变异可能是维吾尔族人代谢综合征的易感基因。
[Abstract]:Objective: to study the relationship between Furin gene functional polymorphism and Uygur metabolic syndrome. Methods: based on the cross-sectional investigation of natural population, 1134 Uygur subjects (including 707 cases of metabolic syndrome and 424 cases of control group) were selected as study objects. It was found from previous studies that the four representative mutation sites of furin gene were re-verified in this study, and genotypic identification and case-control study with TaqMan-PCR were carried out in natural population. Results: rs2071410, a representative mutation site in the functional region of Furin gene, was successfully verified. It was also found that the distribution of rs2071410 genotypes in metabolic syndrome group and control group was statistically different (P0. 010) allele distribution in metabolic syndrome group was significantly different from that in control group (P0. 546). Logistic regression analysis). Adjusted for confounding factors such as TNF-a,BMI, blood pressure blood glucose and rs2071410 it was found that TT genotype was still an independent risk factor for metabolic syndrome (p0. 013). OR=1.471,95% CI 1.297-1.761). There were significant differences in fasting blood glucose, postprandial blood glucose, insulin resistance index and blood LDL, systolic blood pressure between different rs2071410 genotypes (P0.05). Conclusion: the mutation of Furin gene may be associated with metabolic syndrome in Uygur nationality, and it may be a susceptible gene of metabolic syndrome in Uygur nationality.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R589
，
本文编号：2301081
[Abstract]:Objective: to study the relationship between Furin gene functional polymorphism and Uygur metabolic syndrome. Methods: based on the cross-sectional investigation of natural population, 1134 Uygur subjects (including 707 cases of metabolic syndrome and 424 cases of control group) were selected as study objects. It was found from previous studies that the four representative mutation sites of furin gene were re-verified in this study, and genotypic identification and case-control study with TaqMan-PCR were carried out in natural population. Results: rs2071410, a representative mutation site in the functional region of Furin gene, was successfully verified. It was also found that the distribution of rs2071410 genotypes in metabolic syndrome group and control group was statistically different (P0. 010) allele distribution in metabolic syndrome group was significantly different from that in control group (P0. 546). Logistic regression analysis). Adjusted for confounding factors such as TNF-a,BMI, blood pressure blood glucose and rs2071410 it was found that TT genotype was still an independent risk factor for metabolic syndrome (p0. 013). OR=1.471,95% CI 1.297-1.761). There were significant differences in fasting blood glucose, postprandial blood glucose, insulin resistance index and blood LDL, systolic blood pressure between different rs2071410 genotypes (P0.05). Conclusion: the mutation of Furin gene may be associated with metabolic syndrome in Uygur nationality, and it may be a susceptible gene of metabolic syndrome in Uygur nationality.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R589
，
本文编号：2301081
本文链接：https://www.wllwen.com/yixuelunwen/nfm/2301081.html
最近更新
教材专著
