重用碘解磷定治疗口服有机磷农药中毒的临床疗效观察

发布时间：2018-11-03 17:35

【摘要】：目的:观察连续静脉泵入碘解磷定对急性有机磷中毒的疗效,氯解磷定应用于急性有机磷中毒疗效肯定,通过使用碘解磷定与使用氯解磷定作为解毒药物对重度有机磷中毒患者进行比较,从而评价碘解磷定临床解毒疗效,为临床应用此种药物提供更多的数据参考。方法:选择重度有机磷中毒患者52例,其中因氯解磷定药物短缺而使用碘解磷定作为解毒药物26例为实验组,使用氯解磷定作为解毒药物26例设为对照组,分别测量两组患者用药前及应用解毒药物后第1天,用药后第2天,用药后第3天,用药后第4天血浆胆碱酯酶的活性情况,并比较两组患者的阿托品使用总量,平均住院天数、并发症,预后以及两种药物副作用,从而评价碘解磷定的效果。结果:1应用碘解磷定作为解毒药物与应用氯解磷定组相比血浆胆碱酯酶的复活情况无明显差异。2应用碘解磷定作为解毒药物与应用氯解磷定组相比,并没有增加应用阿托品的总药量、未增加患者的住院天数。3碘解磷定组与氯解磷定组相比并没有增加并发症的发生率。4应用碘解磷定与氯解磷定相比,预后情况无差异、局部反应减少。结论:1连续静脉泵入碘解磷定对于治疗急性口服有机磷中毒疗效可靠。2碘解磷定与氯解磷定相比,无论从药物疗效、阿托品用量、患者的住院天数、并发症、预后均无明显差异。未增加不良反应。3碘解磷定的合理应用可以起到氯解磷定一样的治疗效果,可以作为氯解磷定不足时的备用药。4氯解磷定肌肉注射部位疼痛明显,给药方式有待进一步探讨。
[Abstract]:Objective: to observe the efficacy of continuous intravenous infusion of phosphoiodide in the treatment of acute organophosphorus poisoning. In order to evaluate the clinical detoxification efficacy of iodide and chlorophosphoridine as detoxification drugs, the clinical detoxification effect of iodide was evaluated in order to provide more data reference for clinical application of this drug in patients with severe organophosphorus poisoning. Methods: Fifty-two patients with severe organophosphorus poisoning were selected, among them, 26 cases were treated with iodide as detoxification because of shortage of chlorophosphoridine, and 26 cases as control group. The plasma cholinesterase activity before and after detoxification was measured in the two groups, and the total amount of atropine was compared between the two groups, including the first day, the second day, the third day and the fourth day after the treatment. The average length of stay, complications, prognosis, and side effects of both drugs were evaluated. Results: 1 there was no significant difference in the resurrection of plasma cholinesterase between the two groups. The total dosage of atropine was not increased, and the hospital stay was not increased. 3 the incidence of complications was not increased in the iodide group compared with the control group. 4 there was no difference in the prognosis between the two groups. The local reaction was reduced. Conclusion: 1 continuous intravenous infusion of iodide is reliable in the treatment of acute oral organophosphorus poisoning. There was no significant difference in prognosis. No increase in adverse reactions. (3) rational use of iodide can have the same therapeutic effect as chlorophosphoridine, and can be used as a backup drug in the absence of chlorophosphoridine. 4 the pain in the injection site is obvious. The method of administration needs further study.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R595.4

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