3C胰岛素泵治疗脆性糖尿病的临床疗效

发布时间：2018-11-03 21:17

【摘要】：目的探讨3C胰岛素泵与双C方案(胰岛素泵联合回顾性动态血糖监测)治疗脆性糖尿病的疗效与安全性。方法随机选择32例脆性糖尿病患者并分为3C组(16例)和双C组(16例),均治疗6d,比较两组治疗前后血糖水平、血糖波动情况和低血糖发生情况。结果治疗第6天3C组空腹血糖(FPG,(6.3±0.6)mmol/L vs(7.1±0.5)mmol/L]、平均血糖(MBG,(7.87±0.72)mmol/L vs(10.86±1.08)mmol/L]明显低于双C组(P0.05),3C组平均血糖波动幅度(MAGE,(3.79±0.50)mmol/L vs(4.98±0.41)mmol/L)、低血糖风险系数(LGBI,(0.39±0.13)vs(1.08±0.32)]明显低于双C组(P0.05),3C组血糖3.9 mmol/L的药时曲线下面积(AUC,(3.9,0.11±0.04)mmol·L~(-1)·h~(-1)vs(0.49±0.15)mmol·L~(-1)·h~(-1)]明显低于双C组(P0.05)。结论 3C胰岛素泵治疗脆性糖尿病的疗效及安全性明显优于双C方案。
[Abstract]:Objective to investigate the efficacy and safety of 3C insulin pump and double C regimen (insulin pump combined with dynamic blood glucose monitoring) in the treatment of fragile diabetes mellitus. Methods 32 patients with fragile diabetes were randomly divided into 3C group (16 cases) and double C group (16 cases). The blood glucose level, blood glucose fluctuation and hypoglycemia were compared before and after treatment for 6 days. Results on the 6th day, fasting blood glucose (FPG, (6.3 卤0.6) mmol/L vs (7.1 卤0.5 mmol/L) and mean blood glucose (MBG,) in 3C group were measured. (7.87 卤0.72) mmol/L vs (10.86 卤1.08 mmol/L) was significantly lower than that in group C (P0.05). The mean fluctuation of blood glucose in 3C group was 3.79 卤0.50 mmol/L vs (4.98 卤0.41 mmol/L). The hypoglycemic risk coefficient (LGBI, (0.39 卤0.13) vs (1.08 卤0.32) was significantly lower than that of the double C group (P0.05). The area under the drug time curve of 3C group was 3.9 mmol/L (AUC,). (3.9 卤0.04) mmol L ~ (-1) h ~ (-1) vs (0.49 卤0.15 mmol L ~ (-1) h ~ (-1) was significantly lower than that of double C group (P0.05). Conclusion 3C insulin pump is superior to double C regimen in the treatment of fragile diabetes.
【作者单位】：唐山工人医院内分泌一科;
【基金】：2014年河北省医学适用跟踪项目(GL2014-84)
【分类号】：R587.1

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