老年女性2型糖尿病患者尿酸水平、白细胞计数与骨密度的关系
发布时间：2018-11-04 13:18
【摘要】：目的探讨老年女性2型糖尿病(T2DM)患者血尿酸(UA)、白细胞计数与骨密度的关系。方法采用双能X线吸收法测定老年女性T2DM患者及正常对照组患者腰椎及左股骨颈的BMD,检测其空腹及餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、血尿酸(UA)、血清钙(ALP)、血清磷、血清总碱性磷酸酶(ALP)水平、白细胞计数、淋巴细胞计数。结果 (1)老年女性T2DM患者腰椎、左股骨颈BMD值显著低于正常对照组,UA水平显著高于正常对照组(P0.05)。(2)老年女性T2DM患者高UA组L1~L3 BMD值显著低于正常UA组(P0.05)。(3)Logistic回归分析示,年龄、T2DM和血UA是老年女性骨质疏松或骨含量降低的危险因素,而外周白细胞计数则为保护因素(OR值分别为1.108、5.911、1.005、0.689,P0.05)。结论老年女性T2DM患者BMD降低,定期检测血UA水平和外周白细胞计数,可预测老年女性T2DM患者的BMD。
[Abstract]:Objective to investigate the relationship between serum uric acid (UA), leukocyte count and bone mineral density in elderly women with type 2 diabetes mellitus (T2DM). Methods double energy X-ray absorptiometry was used to measure BMD, of lumbar vertebrae and left femoral neck in elderly women with T2DM and normal controls. Fasting and 2 h postprandial blood glucose (Hb A1c) and serum uric acid (UA), were measured. Serum calcium (ALP), serum phosphorus, serum total alkaline phosphatase (ALP), leukocyte count, lymphocyte count. Results (1) the BMD values of lumbar vertebrae and left femoral neck in elderly women with T2DM were significantly lower than those in normal controls. The level of UA was significantly higher than that of the normal control group (P0.05). (2). The L1~L3 BMD value of the elderly women with high UA was significantly lower than that of the normal UA group (P0.05). (3). T2DM and blood UA were the risk factors of osteoporosis or decrease of bone content in elderly women, while peripheral white blood cell count was the protective factor (OR value was 1.108 / 5.9111.005 / 0.689). Conclusion the serum UA level and peripheral white blood cell count are measured regularly in elderly women with T2DM, which can be used to predict BMD. in elderly women with T2DM.
【作者单位】： 石河子大学医学院;石河子大学医学院第一附属医院老年病科;
【分类号】：R580;R587.2
本文编号：2309929
[Abstract]:Objective to investigate the relationship between serum uric acid (UA), leukocyte count and bone mineral density in elderly women with type 2 diabetes mellitus (T2DM). Methods double energy X-ray absorptiometry was used to measure BMD, of lumbar vertebrae and left femoral neck in elderly women with T2DM and normal controls. Fasting and 2 h postprandial blood glucose (Hb A1c) and serum uric acid (UA), were measured. Serum calcium (ALP), serum phosphorus, serum total alkaline phosphatase (ALP), leukocyte count, lymphocyte count. Results (1) the BMD values of lumbar vertebrae and left femoral neck in elderly women with T2DM were significantly lower than those in normal controls. The level of UA was significantly higher than that of the normal control group (P0.05). (2). The L1~L3 BMD value of the elderly women with high UA was significantly lower than that of the normal UA group (P0.05). (3). T2DM and blood UA were the risk factors of osteoporosis or decrease of bone content in elderly women, while peripheral white blood cell count was the protective factor (OR value was 1.108 / 5.9111.005 / 0.689). Conclusion the serum UA level and peripheral white blood cell count are measured regularly in elderly women with T2DM, which can be used to predict BMD. in elderly women with T2DM.
【作者单位】： 石河子大学医学院;石河子大学医学院第一附属医院老年病科;
【分类号】：R580;R587.2
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