非瓣膜性心房颤动合并2型糖尿病患者的临床特征与生存状况研究
发布时间：2018-11-09 08:20
【摘要】：目的探讨非瓣膜性心房颤动(NVAF)并发2型糖尿病(T2DM)患者的临床特点,以及T2DM对NVAF患者生存状况的影响。方法选取2014年1月至2015年9月天津市胸科医院收治的646例NVAF患者,根据患者是否合并T2DM将其分为T2DM组(n=110)与非T2DM组(n=536)。比较两组的临床资料及随访1年脑梗死、心血管死亡的发生率,采用多因素Cox比例风险模型筛选影响患者1年内脑梗死、心血管死亡发生的因素。结果 T2DM组患者的年龄、体质量指数,高血压、冠心病、短暂性脑缺血发作(TIA)或脑卒中、高脂血症的发生率,以及阿司匹林、他汀类降脂药的应用率均明显高于非T2DM组,差异均有统计学意义(P0.05)。随访1年,T2DM组患者心血管死亡的发生率为14.5%,明显高于非T2DM组的5.1%(P0.05)。T2DM组、非T2DM组患者脑梗死的发生率分别为12.7%、6.4%,组间比较差异无统计学意义(P0.05)。多因素Cox回归分析结果表明,年龄、TIA或脑卒中、T2DM是脑梗死发生的独立危险因素(P0.05)。年龄、心力衰竭、T2DM是心血管死亡发生的独立危险因素,而血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体阻滞剂是其独立保护因素(P0.05)。结论合并T2DM可增加NVAF患者脑梗死与心血管死亡的风险。
[Abstract]:Objective to investigate the clinical features of (NVAF) complicated with type 2 diabetes mellitus (T2DM) and the influence of T2DM on the survival status of NVAF patients with non-valvular atrial fibrillation. Methods from January 2014 to September 2015, 646 patients with NVAF were selected and divided into T2DM group (n = 110) and non-T2DM group (n = 536) according to whether they were combined with T2DM. The clinical data and the incidence of cerebral infarction and cardiovascular death were compared between the two groups. The risk factors of cerebral infarction and cardiovascular death within one year were screened by multivariate Cox proportional risk model. Results the age, body mass index, hypertension, coronary heart disease, transient ischemic attack of (TIA) or stroke, hyperlipidemia and the application rate of aspirin and statins in T2DM group were significantly higher than those in non-T2DM group. The difference was statistically significant (P0.05). After 1 year follow-up, the incidence of cardiovascular death in T2DM group was 14.5%, which was significantly higher than that in non-T2DM group (5.1%). The incidence of cerebral infarction in T2DM group and non-T2DM group was 12.7% and 6.4%, respectively. There was no significant difference between the two groups (P0.05). Multivariate Cox regression analysis showed that age, TIA or stroke, T2DM were independent risk factors of cerebral infarction (P0.05). Age, heart failure and T2DM were independent risk factors for cardiovascular death, while angiotensin converting enzyme inhibitors / angiotensin 鈪，
本文编号：2319866
[Abstract]:Objective to investigate the clinical features of (NVAF) complicated with type 2 diabetes mellitus (T2DM) and the influence of T2DM on the survival status of NVAF patients with non-valvular atrial fibrillation. Methods from January 2014 to September 2015, 646 patients with NVAF were selected and divided into T2DM group (n = 110) and non-T2DM group (n = 536) according to whether they were combined with T2DM. The clinical data and the incidence of cerebral infarction and cardiovascular death were compared between the two groups. The risk factors of cerebral infarction and cardiovascular death within one year were screened by multivariate Cox proportional risk model. Results the age, body mass index, hypertension, coronary heart disease, transient ischemic attack of (TIA) or stroke, hyperlipidemia and the application rate of aspirin and statins in T2DM group were significantly higher than those in non-T2DM group. The difference was statistically significant (P0.05). After 1 year follow-up, the incidence of cardiovascular death in T2DM group was 14.5%, which was significantly higher than that in non-T2DM group (5.1%). The incidence of cerebral infarction in T2DM group and non-T2DM group was 12.7% and 6.4%, respectively. There was no significant difference between the two groups (P0.05). Multivariate Cox regression analysis showed that age, TIA or stroke, T2DM were independent risk factors of cerebral infarction (P0.05). Age, heart failure and T2DM were independent risk factors for cardiovascular death, while angiotensin converting enzyme inhibitors / angiotensin 鈪，
本文编号：2319866
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