等能量摄食条件下不同膳食脂肪供能比对大鼠血糖、血脂的影响

发布时间：2018-11-09 08:48

【摘要】：目的探讨等能量摄食条件下不同膳食脂肪供能比对大鼠血糖和血脂等指标的影响。方法将40只雄性SD大鼠按随机区组法分为低脂饲料、普通饲料、中脂饲料和高脂饲料组4组,等能量饲喂脂肪供能比分别为5%、15%、25%、40%的饲料10周。每周测大鼠体重和体长,第0、5和10周取尾血测空腹血糖、血脂和胰岛素水平,第10周末取肾周及附睾周脂肪称重,计算体脂比。结果实验第5、10周,大鼠体重、Lee's指数、体脂比、血清胰岛素和低密度脂蛋白胆固醇水平在各组间差异无统计学意义;第10周,高脂组血糖与低脂组相比显著升高(P0.01);高脂组总胆固醇、甘油三酯、高密度脂蛋白胆固醇与低脂组相比显著降低(P0.01);第10周,高脂组血糖与0周相比升高(P0.05),高脂组总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇与0周相比降低(P0.01)。结论在等能量摄食、正常生长条件下,高脂肪供能比饲料不会引起大鼠肥胖,但可能会导致大鼠糖脂水平的改变。
[Abstract]:Objective to investigate the effects of different dietary fat energy ratios on blood glucose and blood lipid in rats. Methods Forty male SD rats were randomly divided into four groups: low fat diet, normal diet, medium fat diet and high fat feed group. The body weight and body length were measured weekly, fasting blood glucose, blood lipids and insulin levels were measured at the 5th and 10th weeks, and the fat weights around kidney and epididymis were taken at the 10th week to calculate the ratio of body fat to fat. Results there was no significant difference in body weight, Lee's index, body fat ratio, serum insulin and low density lipoprotein cholesterol levels between the groups. At the 10th week, the blood glucose in the high fat group was significantly higher than that in the low fat group (P0.01), the total cholesterol, triglyceride and high density lipoprotein cholesterol in the high fat group were significantly lower than those in the low fat group (P0.01). In the 10th week, the blood glucose in the hyperlipidemia group was higher than that in the 0 week group (P0.05), the total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol in the high fat group were lower than those in the 0 week group (P0.01). Conclusion under the condition of equal energy intake and normal growth, high fat energy supply can not cause obesity in rats, but may result in the change of glucose and lipid levels in rats.
【作者单位】：中国疾病预防控制中心营养与健康所国家卫生计生委微量元素重点实验室;北京市海淀区卫生和计划生育监督所;
【基金】：国家自然科学基金(No.81372992)
【分类号】：R589.2

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