老年糖尿病与遗忘型轻度认知功能障碍的相关性

发布时间：2018-11-16 10:58

【摘要】：目的探讨老年糖尿病与遗忘型轻度认知功能障碍(a MCI)的相关性。方法采用前瞻性随访队列研究设计。共纳入符合研究目的且资料完整的老年对象416例,分析老年糖尿病患者不同临床特征与a MCI的相关性。结果老年糖尿病能够明显增加a MCI[HR(95%CI):1.82(1.05~3.17),P=0.032]、单个认知领域损伤a MCI[HR(95%CI):2.35(1.18~4.68),P=0.013]及多个认知领域损伤a MCI[HR(95%CI):2.40(1.00~5.81),P=0.045]的发生风险。老年糖尿病更能引起男性多个认知领域损伤a MCI的发生[HR(95%CI):3.60(1.04~12.45),P=0.032]。糖尿病患者患病年龄≤65[HR(95%CI):2.52(1.01~6.30),P=0.042]、血糖调控失衡[HR(95%CI):3.58(1.26~10.19),P=0.011]、口服降糖药[HR(95%CI):2.23(1.06~4.72),P=0.032]、胰岛素治疗[HR(95%CI):2.87(1.06~7.78),P=0.032]、视网膜病变[HR(95%CI):3.41(1.01~11.49),P=0.036]及神经病变[HR(95%CI):2.63(110~6.32),P=0.025]是a MCI的危险因素。结论老年糖尿病能够明显增加a MCI发生风险,男性患者发生a MCI的风险更高,尤其是多个认知领域损伤a MCI,护理中应更加关注男性糖尿病患者。
[Abstract]:Objective to investigate the correlation between senile diabetes mellitus and amnesia mild cognitive impairment (a MCI). Methods prospective follow-up cohort study was used. A total of 416 elderly subjects with complete data were included to analyze the correlation between different clinical features and a MCI in elderly patients with diabetes mellitus. Results there was a significant increase in a MCI [HR (95%CI): 1.82 (1.05v 3.17), P0.032], and a MCI injury in single cognitive domain [HR (95%CI): 2.35 (1.184.68)]. The risk of multiple cognitive impairment a MCI [HR (95%CI): 2.40 (1.005.81), P0. 045]. Diabetes mellitus in the elderly may cause multiple cognitive domain impairment a MCI in men [HR (95%CI): 3.60 (1.04v 12.45), P0. 032]. Age 鈮，

本文编号：2335329