中性粒细胞与淋巴细胞比值及红细胞分布宽度对亚甲炎的诊断价值研究
发布时间：2018-11-19 21:16
【摘要】：目的探讨中性粒细胞与淋巴细胞比值(NLR)及红细胞分布宽度(RDW)对亚甲炎的诊断价值。方法回顾性分析2014年4月-2016年10月河南中医药大学第二附属医院收治的89例亚甲炎患者作为研究组,另选取78例其他甲状腺疾病患者和80例健康体检者,比较各组中的红细胞分布宽度(RDW)、中性粒细胞与淋巴细胞比值(NLR)、甲状腺球蛋白(Tg)、甲状腺结合球蛋白抗体(TG-Ab)、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺激素受体抗体(TRAb)、甲状腺微粒体抗体(TMAb)以及FT3、FT4、TSH之间的差异关系,采用Pearson相关分析及多元逐步线性回归分析RDW、NLR与其他指标的关系,采用ROC曲线来比较各指标的诊断价值。结果亚甲炎组和其他组的RDW值均高于正常对照组,而NLR值则低于正常对照组;RDW与TSH、TPOAb分别具有相关性,相关系数分别为-0.43和0.33(P0.05);NLR与FT3则呈现正相关,相关系数为0.47(P0.05);ROC分析曲线表明,Tg是亚甲炎的最佳诊断指标,RDW,NLR也可作为较佳诊断指标。结论 NLR、RDW联合Tg,更能对亚甲炎做出有效诊断,对于联合性分析具有一定的价值。
[Abstract]:Objective to investigate the diagnostic value of neutrophil / lymphocyte ratio (NLR) and erythrocyte distribution width (RDW) in subthyroiditis. Methods from April 2014 to October 2016, 89 patients with subthyroiditis admitted in the second affiliated Hospital of Henan University of traditional Chinese Medicine were selected as the study group, 78 patients with other thyroid diseases and 80 healthy controls were selected. (NLR), thyroglobulin (Tg), thyroid binding globulin antibody (TG-Ab) and thyroid peroxidase antibody (TPOAb), were compared in each group by comparing the red blood cell distribution width (RDW), neutrophil / lymphocyte ratio (NLR), thyroglobulin (Tg), thyroid binding globulin antibody (TG-Ab) and thyroid peroxidase antibody (TPOAb), The difference of (TMAb) and FT3,FT4,TSH between (TRAb), thyroid microsomal antibody and FT3,FT4,TSH was studied. The relationship between RDW,NLR and other indexes was analyzed by Pearson correlation analysis and multiple stepwise linear regression analysis. ROC curve was used to compare the diagnostic value of each index. Results the RDW value of subthyroitis group and other groups were higher than that of normal control group, but the NLR value was lower than that of normal control group, RDW and TSH,TPOAb had correlation coefficient of -0.43 and 0.33 (P0.05). There was a positive correlation between NLR and FT3, the correlation coefficient was 0.47 (P0.05); ROC analysis curve showed that Tg is the best diagnostic index of subthyroiditis, RDW,NLR can also be used as a better diagnostic index. Conclusion NLR,RDW combined with Tg, is more effective in the diagnosis of thyroiditis.
【作者单位】： 河南中医药大学第二附属医院检验科;
【基金】：河南省科技攻关项目(132102310244)
【分类号】：R446.1;R581.4
本文编号：2343450
[Abstract]:Objective to investigate the diagnostic value of neutrophil / lymphocyte ratio (NLR) and erythrocyte distribution width (RDW) in subthyroiditis. Methods from April 2014 to October 2016, 89 patients with subthyroiditis admitted in the second affiliated Hospital of Henan University of traditional Chinese Medicine were selected as the study group, 78 patients with other thyroid diseases and 80 healthy controls were selected. (NLR), thyroglobulin (Tg), thyroid binding globulin antibody (TG-Ab) and thyroid peroxidase antibody (TPOAb), were compared in each group by comparing the red blood cell distribution width (RDW), neutrophil / lymphocyte ratio (NLR), thyroglobulin (Tg), thyroid binding globulin antibody (TG-Ab) and thyroid peroxidase antibody (TPOAb), The difference of (TMAb) and FT3,FT4,TSH between (TRAb), thyroid microsomal antibody and FT3,FT4,TSH was studied. The relationship between RDW,NLR and other indexes was analyzed by Pearson correlation analysis and multiple stepwise linear regression analysis. ROC curve was used to compare the diagnostic value of each index. Results the RDW value of subthyroitis group and other groups were higher than that of normal control group, but the NLR value was lower than that of normal control group, RDW and TSH,TPOAb had correlation coefficient of -0.43 and 0.33 (P0.05). There was a positive correlation between NLR and FT3, the correlation coefficient was 0.47 (P0.05); ROC analysis curve showed that Tg is the best diagnostic index of subthyroiditis, RDW,NLR can also be used as a better diagnostic index. Conclusion NLR,RDW combined with Tg, is more effective in the diagnosis of thyroiditis.
【作者单位】： 河南中医药大学第二附属医院检验科;
【基金】：河南省科技攻关项目(132102310244)
【分类号】：R446.1;R581.4
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