基于TRPM8通道研究薄荷醇对哮喘小鼠气道反应性及肺组织病理学的影响
发布时间：2018-11-20 06:05
【摘要】：研究TRPM8通道在支气管哮喘发病机制中的作用,以及薄荷醇(Menthol)对哮喘小鼠气道反应性及肺组织病理学的影响。观察Menthol对TRPM8野生型(+/+)和敲除型(-/-)小鼠气道反应性及肺组织病理学改变的影响。Menthol可缓解肺组织病理进程,而Menthol对TRPM8-/-型哮喘小鼠无改善作用。
[Abstract]:To study the role of TRPM8 channel in the pathogenesis of bronchial asthma and the effect of menthol (Menthol) on airway responsiveness and lung histopathology in asthmatic mice. To observe the effect of Menthol on airway reactivity and lung histopathological changes in TRPM8 wild-type (/) and knockout (- / -) mice, Menthol could alleviate the pathological process of lung tissue, but Menthol had no effect on TRPM8-/- asthmatic mice.
【作者单位】： 南阳理工学院;
【基金】：高等学校博士学科点专项科研基金(20103107110008)资助
【分类号】：R562.25
，
本文编号：2344001
[Abstract]:To study the role of TRPM8 channel in the pathogenesis of bronchial asthma and the effect of menthol (Menthol) on airway responsiveness and lung histopathology in asthmatic mice. To observe the effect of Menthol on airway reactivity and lung histopathological changes in TRPM8 wild-type (/) and knockout (- / -) mice, Menthol could alleviate the pathological process of lung tissue, but Menthol had no effect on TRPM8-/- asthmatic mice.
【作者单位】： 南阳理工学院;
【基金】：高等学校博士学科点专项科研基金(20103107110008)资助
【分类号】：R562.25
，
本文编号：2344001
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