双源CT双能量成像与血清超敏C反应蛋白在老年痛风诊断中的价值

发布时间：2018-11-21 15:02

【摘要】：目的探究双源CT双能量成像(DECT)和血清超敏C反应蛋白(hs-CRP)诊断老年痛风的临床价值。方法 300例痛风老年患者为观察组,同期38例非痛风老年患者作为对照组,进行DECT检查和血清指标检测。根据DECT对痛风检查结果计算出相应的灵敏特异度;比较两组血清白细胞介素(IL)-18、IL-1β及hs-CRP水平;分析IL-18、IL-1β及hs-CRP对痛风的诊断的灵敏特异度;对比血清指标与DECT对痛风诊断价值。结果观察组IL-18、IL-1β及hs-CRP水平显著高于对照组(均P0.05),但受试者工作特征(ROC)曲线显示当hs-CRP诊断分界点取值1.99 mg/L时诊断灵敏度为85.43%,特异度为77.14%,诊断价值均好于IL-18、IL-1β;根据发现尿酸盐结晶为诊断痛风的标准得出,DECT诊断的灵敏度88.33%、特异度97.37%及准确率89.35%,且均高于hs-CRP。结论 DECT检查诊断痛风老年患者相对于血清hs-CRP检测具有更高的准确率及诊断价值,且操作快速简便,可作为早期筛查诊断痛风的方法。
[Abstract]:Objective to explore the clinical value of dual source CT dual energy imaging (DECT) and serum hypersensitive C reactive protein (hs-CRP) in the diagnosis of senile gout. Methods 300 cases of gout aged patients as observation group and 38 cases of non-gout elderly patients as control group were examined with DECT and serum indexes. According to the results of DECT, the sensitivity and specificity of gout were calculated, the serum levels of interleukin-1 尾 (IL) 18) and interleukin-1 尾 (hs-CRP) were compared between the two groups, and the sensitivity and specificity of IL-18,IL-1 尾 and hs-CRP in the diagnosis of gout were analyzed. To compare the value of serum index and DECT in the diagnosis of gout. Results the levels of IL-18,IL-1 尾 and hs-CRP in the observation group were significantly higher than those in the control group (P0.05), but the diagnostic sensitivity was 85.43 when the diagnostic threshold value of hs-CRP was 1.99 mg/L. The specificity was 77.14, and the diagnostic value was better than that of IL-18,IL-1 尾. According to the criteria for the diagnosis of gout, the sensitivity, specificity and accuracy of DECT were 88.33, 97.37% and 89.35, respectively, which were higher than those of hs-CRP.. Conclusion DECT has higher accuracy and diagnostic value than serum hs-CRP in elderly patients with gout, and it can be used as an early screening method for the diagnosis of gout.
【作者单位】：濮阳市人民医院风湿免疫科;濮阳市医学高等专科学校;
【基金】：濮阳市科技计划项目(No.140639)
【分类号】：R589.7

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